ID A0A1Q5I9S0_9ACTN Unreviewed; 232 AA.
AC A0A1Q5I9S0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Urease subunit gamma/beta {ECO:0000256|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000256|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit gamma/beta {ECO:0000256|HAMAP-Rule:MF_01955};
GN Name=ureAB {ECO:0000256|HAMAP-Rule:MF_01955};
GN ORFNames=AMK29_30045 {ECO:0000313|EMBL:OKJ53844.1};
OS Streptomyces sp. CB02261.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ53844.1, ECO:0000313|Proteomes:UP000186742};
RN [1] {ECO:0000313|EMBL:OKJ53844.1, ECO:0000313|Proteomes:UP000186742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02261 {ECO:0000313|EMBL:OKJ53844.1,
RC ECO:0000313|Proteomes:UP000186742};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000242, ECO:0000256|HAMAP-
CC Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000256|ARBA:ARBA00004897,
CC ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta)
CC subunits. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ53844.1}.
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DR EMBL; LIVX01000011; OKJ53844.1; -; Genomic_DNA.
DR RefSeq; WP_073819128.1; NZ_LIVX01000011.1.
DR AlphaFoldDB; A0A1Q5I9S0; -.
DR OrthoDB; 9797217at2; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000186742; Unassembled WGS sequence.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; Urease, beta subunit; 1.
DR Gene3D; 3.30.280.10; Urease, gamma-like subunit; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR InterPro; IPR002019; Urease_beta-like.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR NCBIfam; TIGR00193; urease_gam; 1.
DR PANTHER; PTHR33569; UREASE; 1.
DR PANTHER; PTHR33569:SF1; UREASE; 1.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; Urease, beta-subunit; 1.
DR SUPFAM; SSF54111; Urease, gamma-subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01955}.
FT REGION 1..101
FT /note="Urease gamma"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
FT REGION 102..232
FT /note="Urease beta"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
SQ SEQUENCE 232 AA; 24002 MW; EEAE2EF76D021A5D CRC64;
MRLTPTERDR LLLFGAAELA RARRARGLRL NVPEATALIA DTVCEAARDG KRLAEAIDAA
RSVLGPDDVL PGVADVVTEV HVEAVFDDGS RLAVVSDPIG GGGLGEGAPG ALLPGPGHPE
TEPALTLRVR NTATVPVSVT SHFHFFEVNP RLDFDRAATY GMRLAIPAGA SFRFDPGGEA
EVGLVPIGGA RVAIGFAGLV DGPLDAPGAR EEALRRAAAC GYLGVPSDEE GN
//
