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Database: UniProt
Entry: A0A1Q5J3M5_9ACTN
LinkDB: A0A1Q5J3M5_9ACTN
Original site: A0A1Q5J3M5_9ACTN 
ID   A0A1Q5J3M5_9ACTN        Unreviewed;       456 AA.
AC   A0A1Q5J3M5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE            EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE   AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE   AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE   AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE   AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN   ORFNames=AMK29_17620 {ECO:0000313|EMBL:OKJ63936.1};
OS   Streptomyces sp. CB02261.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ63936.1, ECO:0000313|Proteomes:UP000186742};
RN   [1] {ECO:0000313|EMBL:OKJ63936.1, ECO:0000313|Proteomes:UP000186742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02261 {ECO:0000313|EMBL:OKJ63936.1,
RC   ECO:0000313|Proteomes:UP000186742};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC         Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC         ChEBI:CHEBI:58349; EC=1.14.13.59;
CC         Evidence={ECO:0000256|ARBA:ARBA00000168};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC   -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC       oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ63936.1}.
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DR   EMBL; LIVX01000005; OKJ63936.1; -; Genomic_DNA.
DR   RefSeq; WP_073814011.1; NZ_LIVX01000005.1.
DR   AlphaFoldDB; A0A1Q5J3M5; -.
DR   OrthoDB; 7527071at2; -.
DR   Proteomes; UP000186742; Unassembled WGS sequence.
DR   GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR025700; Lys/Orn_oxygenase.
DR   PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR   PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR   Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR   PRINTS; PR00368; FADPNR.
DR   PRINTS; PR00411; PNDRDTASEI.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE   3: Inferred from homology;
KW   Monooxygenase {ECO:0000313|EMBL:OKJ63936.1};
KW   Oxidoreductase {ECO:0000313|EMBL:OKJ63936.1}.
SQ   SEQUENCE   456 AA;  50503 MW;  614A8C321E93BAAC CRC64;
     MSQVPPGDAP LVHDLIGIGF GPSNVAMAIA LSEHNARVGR QEAVTAHFFE RQPRFGWHRG
     MLIDDATMQV SFLKDLVTLR NPTSEYSFLC YLQSKGRLID FVNHKNLFPL RVEFHDYFEW
     AASKVDDMVS YGHEIISVEP VERDGVVEYL DVTARSGSEL VVHRARNLVL GTGLRPRMPE
     GVERSDRVWH NSDLLAKVEG LDGTAPERFV VVGAGQSAAE NVAYLHRRFP EAEICAVFSR
     YGYSPADDSA FANRIFDPDA VDEYFTAPDD IKRKLMDYHG NTNYSVVDID LIDDLYRQAY
     QEKVLGTERL RFLNISRLTG VEDGPDKVRA FVTSLVTGEE TALDADVVVY ATGYSPAEPL
     GLLGPVADRC HRDDQGRVRV ERDYRLATDP EVRCGIYLQG GTEHTHGITS SLLSNTAIRV
     GEILASVLDR NPAATAAELS TADEARPMAD GVGTAR
//
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