ID A0A1Q5JA25_9ACTN Unreviewed; 786 AA.
AC A0A1Q5JA25;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=AMK29_16075 {ECO:0000313|EMBL:OKJ66201.1};
OS Streptomyces sp. CB02261.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ66201.1, ECO:0000313|Proteomes:UP000186742};
RN [1] {ECO:0000313|EMBL:OKJ66201.1, ECO:0000313|Proteomes:UP000186742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02261 {ECO:0000313|EMBL:OKJ66201.1,
RC ECO:0000313|Proteomes:UP000186742};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ66201.1}.
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DR EMBL; LIVX01000004; OKJ66201.1; -; Genomic_DNA.
DR RefSeq; WP_073813382.1; NZ_LIVX01000004.1.
DR AlphaFoldDB; A0A1Q5JA25; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000186742; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 468..771
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 786 AA; 84329 MW; 2F68E9B39A514A4F CRC64;
MQERLHDPYV RVRGAREHNL AGVDVDIPRD ALVAFTGVSG SGKSSLAFGT IYAEAQRRYF
ESVAPYARRL IHQVGAPAVG EITGLPPAVS LEQRRSSPNA RSSVGTVTTL SNSLRMLFSR
AGRYPEGAER LDSDSFSPNT AVGACPSCHG LGRVHDTSEE LLVPDPELSI RQGAIAAWPG
AWQGKNLRDV LDTLGYDVDR PWRELDAKDR EWILFTEEQP VVTVHPVRDA DRIQRPYQGT
YMSARRYVLR TFSDSKSPTL RTKAERFLTS APCPVCGGAR LRPEALAVTF AGRTIAELAG
LPLTTLSGLL AEAGAEGTET ARVLTADLVA RIVTVTELGL GYLSLDRATP TLSNGELQRL
RLATQLRSGL FGVVYVLDEP SAGLHPADTE ALLVVLDRLK AAGNSVFVVE HHLDVIRHAD
WLVDVGPHAG VHGGRVLHSG PPDGLAEVEA SATRRFLFDR APAPGREVRE PAGWLRTGPV
TRHNLRAVDA AFPVGVLTAV TGVSGSGKST LVGALTEEVA GVERLVTVDQ RPIGRTPRSN
LATYTGLFDV VRKLFTETEE ARARGYKAGR FSFNVTGGRC ETCQGEGFVS VELLFLPSTY
APCPDCHGAR YNPETLEVRL RGLTIAEVLD LTVEAAAAFF DDTPAAARSL RALLDVGLGY
LRLGQPATEL SGGEAQRIKL ASELQRPHRS PTLYVLDEPT TGLHPADVEV LMRQLHGLVD
AGHSVVVVEH DMDVVATADW VVDLGPGGGD EGGRIVAAGP PDRVARAAGS RTALYLARST
GLAGRP
//