ID A0A1Q5JIB0_9ACTN Unreviewed; 486 AA.
AC A0A1Q5JIB0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glutamate synthase {ECO:0000313|EMBL:OKJ69074.1};
DE EC=1.4.1.13 {ECO:0000313|EMBL:OKJ69074.1};
GN Name=gltD {ECO:0000313|EMBL:OKJ69074.1};
GN ORFNames=AMK29_01080 {ECO:0000313|EMBL:OKJ69074.1};
OS Streptomyces sp. CB02261.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ69074.1, ECO:0000313|Proteomes:UP000186742};
RN [1] {ECO:0000313|EMBL:OKJ69074.1, ECO:0000313|Proteomes:UP000186742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02261 {ECO:0000313|EMBL:OKJ69074.1,
RC ECO:0000313|Proteomes:UP000186742};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ69074.1}.
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DR EMBL; LIVX01000001; OKJ69074.1; -; Genomic_DNA.
DR RefSeq; WP_073806696.1; NZ_LIVX01000001.1.
DR AlphaFoldDB; A0A1Q5JIB0; -.
DR OrthoDB; 9803192at2; -.
DR Proteomes; UP000186742; Unassembled WGS sequence.
DR GO; GO:0004355; F:glutamate synthase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0006537; P:glutamate biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR028261; DPD_II.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR006005; Glut_synth_ssu1.
DR InterPro; IPR009051; Helical_ferredxn.
DR NCBIfam; TIGR01317; GOGAT_sm_gam; 1.
DR PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR Pfam; PF14691; Fer4_20; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Glutamate biosynthesis {ECO:0000256|ARBA:ARBA00023164};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:OKJ69074.1}.
FT DOMAIN 40..129
FT /note="Dihydroprymidine dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF14691"
FT DOMAIN 147..456
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
SQ SEQUENCE 486 AA; 52328 MW; 56191680F91738BF CRC64;
MADPKGFLTT GREVAETRPV AERVRDWNEV YVPGSLLPII SKQAGRCMDC GIPFCHNGCP
LGNLIPEWND YAYREDWSAA QERLHATNNF PEFTGRLCPA PCESACVLGI NQPAVTIKNV
EVSIIDKAWD GGDVKPQVPE RLSGKTAAVI GSGPAGLAAA QQLTRAGHTV VVYERADRIG
GLLRYGIPEF KMEKRHINRR IEQMRAEGTK FRTGIEIGRD LTATDLRKRF DAVVIAAGAT
TARDLPVPGR ELNGIHQAME YLPLANKVVE GDFVAPPITA EGKHVVVIGG GDTGADCVGT
AHRQGAASVT QLEIMPRPGE ERNAGQPWPT FPMLYKVTSA HEEGGERVYS VSTTHFEGDE
DGNVQSLHLV EVEFVDGKLT QKPGTERSIP AQLVTLAMGF TGTDVENGLV AQFGLDLDER
GNIARDADFA TNVDGVYVAG DAGRGQSLIV WAIAEGRSAA RGVDRYLTGA SSLPAPIRPT
DRSLTV
//
