ID A0A1Q5JJD6_9ACTN Unreviewed; 420 AA.
AC A0A1Q5JJD6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Pyridine nucleotide-disulfide oxidoreductase {ECO:0000313|EMBL:OKJ69427.1};
GN ORFNames=AMK29_03095 {ECO:0000313|EMBL:OKJ69427.1};
OS Streptomyces sp. CB02261.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703940 {ECO:0000313|EMBL:OKJ69427.1, ECO:0000313|Proteomes:UP000186742};
RN [1] {ECO:0000313|EMBL:OKJ69427.1, ECO:0000313|Proteomes:UP000186742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02261 {ECO:0000313|EMBL:OKJ69427.1,
RC ECO:0000313|Proteomes:UP000186742};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ69427.1}.
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DR EMBL; LIVX01000001; OKJ69427.1; -; Genomic_DNA.
DR RefSeq; WP_073807084.1; NZ_LIVX01000001.1.
DR AlphaFoldDB; A0A1Q5JJD6; -.
DR OrthoDB; 1145at2; -.
DR Proteomes; UP000186742; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR028202; Reductase_C.
DR PANTHER; PTHR43557; APOPTOSIS-INDUCING FACTOR 1; 1.
DR PANTHER; PTHR43557:SF2; RIESKE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF14759; Reductase_C; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE 4: Predicted;
FT DOMAIN 8..313
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 333..418
FT /note="Reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14759"
SQ SEQUENCE 420 AA; 45064 MW; 336EB14AFDDD9236 CRC64;
MVDADQTFVI VGGGLAGAKA AETLRSEGFN GRVILIGDER DHPYERPPLS KGYLTGAKER
DSAFVHDAAW YAANDIELHL GQPVTAVDRE ARTVLLGDNT VIRYDKLLLA TGSEPRRLDV
PGTELAGVHH LRRLAHADRL RQVLSGLGRD NGHLVIAGAG WIGLEVAAAA RGYGAEVTVV
ESDPTPLHRV LGPELGQLFA DLHTDHGVRF HFGVRLTEIV GQDGMVLAVR TDDGEEHPAH
AVLAAIGAAP RTALAENSGL ALVDRADGGG VAVDESLRTS DPDIYAAGDI AAAHHPLLHT
RLRVEHWANA LNGGPAAARA MLGQPVSYDR VPYFFSDQYD LGMEYSGWAP PGTYDQVVVR
GDTGKREFIA FWLKEGRVLA GMNVNVWDVT DPIQRIIRSK AAVHPDALAD PSVPLDSLIP
//
