ID A0A1Q5K559_9ACTN Unreviewed; 655 AA.
AC A0A1Q5K559;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:OKJ76710.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:OKJ76710.1};
GN ORFNames=AMK32_31730 {ECO:0000313|EMBL:OKJ76710.1};
OS Streptomyces sp. CB01883.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703943 {ECO:0000313|EMBL:OKJ76710.1, ECO:0000313|Proteomes:UP000186398};
RN [1] {ECO:0000313|EMBL:OKJ76710.1, ECO:0000313|Proteomes:UP000186398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01883 {ECO:0000313|EMBL:OKJ76710.1,
RC ECO:0000313|Proteomes:UP000186398};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ76710.1}.
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DR EMBL; LIWA01000008; OKJ76710.1; -; Genomic_DNA.
DR RefSeq; WP_073899212.1; NZ_LIWA01000008.1.
DR AlphaFoldDB; A0A1Q5K559; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000186398; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OKJ76710.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186398}.
FT DOMAIN 41..97
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 99..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 539..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 655 AA; 72018 MW; 08A4CC6073E0EEDE CRC64;
MSTANPQPLW QPDPERIAQA RITQFQAWAA EHHGAPAEGG YPALHQWSVE QLDTFWKAVT
EWFDVRFSTP YARVLGDRSM PGAEWFPGAT LNYAEHALRA ADDRPGEPAL LHVDETHEPR
PVTWSELRRQ VGSLAAELRT LGVRPGDRVS GYLPNIPEAV VALLATAAVG GVWTSCAPDF
GARSVLDRFQ QVEPVVLFTV DGYRYGGKEH DRRETVAELR RELPTLRAVV HIPLLGTETP
DGALEWSALT AGDTAPVFEQ VPFDHPLWVL YSSGTTGLPK AIVQSQGGIL VEHLKQLGLH
CDLGPEDRFF WYTSTGWMMW NFLVSGLLTG TTVVLYDGSP GYPDTGAQWR IAERTGATLY
GTSAAYVMAC RKTGVHPSRD FDLSKVRCVA TTGSPLPPDG FRWLHDEVRD DLWIASVSGG
TDVCSCFAGA VPTLPVYTGE LQAPGLGTDL QSWDPSGKPL VDEVGELVVT NPMPSMPIHF
WNDGDGSRYH DSYFDTYPGV WRHGDWITVT GRGSVIIHGR SDSTLNRQGV RMGSADIYEV
VERLPEIRES LVIGIEQPDG GYWMPLFVHL APGAALDEAL LGRIKQAIRE QLSPRHVPDE
VIEVPGIPHT LTGKRIEVPV KRLLQGTPLE KAVNAGSIDN LALLGFYEEL ARKRG
//
