ID A0A1Q5KKU5_9ACTN Unreviewed; 2704 AA.
AC A0A1Q5KKU5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=AMK32_20465 {ECO:0000313|EMBL:OKJ82129.1};
OS Streptomyces sp. CB01883.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703943 {ECO:0000313|EMBL:OKJ82129.1, ECO:0000313|Proteomes:UP000186398};
RN [1] {ECO:0000313|EMBL:OKJ82129.1, ECO:0000313|Proteomes:UP000186398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01883 {ECO:0000313|EMBL:OKJ82129.1,
RC ECO:0000313|Proteomes:UP000186398};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ82129.1}.
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DR EMBL; LIWA01000004; OKJ82129.1; -; Genomic_DNA.
DR Proteomes; UP000186398; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd12117; A_NRPS_Srf_like; 3.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000186398}.
FT DOMAIN 513..588
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1563..1638
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2613..2688
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2704 AA; 291060 MW; C33EB5A63D3DF578 CRC64;
MDAYNSTAVR LPEGALHELF AAQAVRTPDA VALVCGDREL SYRELDTAAT VLAHRLQARG
VRPGDSVGLF QDRSLAYVVA VLAVLRAGGA YIPLDPRQPE ERRAFILADT GAVLLLTDRD
ERATEFAGTV PVLRLTDEVT EPAKEAPPLE VAVHPDQLAY VMYTSGSSGT PKGVANTHRN
VVELALDPWW GVEGRHARVL AYSPLAFDSS TYELWVPLLS GGTAIVLPAP KLDIAELASA
ITEHRATAVY FTTALFDAMA SEAVGALAGL REIWTGGDVL SAPALRRVLE ECPETTVVHA
YGPTESTVFC SYQVFGPQER SVERLHLGVP MANTRMYVLD EGLRPVVPGV VGELYVAGSH
LAWGYVGRPG LSSERFVADP FGPAGERMYR TGDLARWNEH GEVVFEGRAD QQVKLRGFRI
ELGEIETALV AHASVSQAAV IVREDRPGDK RLVAYVVGEA DADTLHDHCA ERLAEYMVPS
AFVLLPELPL TANGKLDRRA LPAPRAGGAE GRAPRTPAEE VLCGLFADIL GVPAVSVDDD
FFRLGGHSLL ATRLVGRVRT ALATELSLRD FFQYPTVARL AEHIATGAGR APRPQLTVAP
RADDHLPLSA AQRRLWFLDQ MEGPSATYNI PLAVTLSGSV DPELLRQALG DVIARHEVLR
TSYPVHDGEP RQHIADPDEV SVPLTVASVS EDDLTGRIAG EAAHLFDLAT ELPLHAALFQ
LEPTRSVLVL VVHHIASDGW SNTPLMRDLG TAYAARAEGG RPGWEPLPVQ YADYALWQRD
LLAEHEDTQL DHWRTALAAL PAESTLPADR PRPAVASYRG TTHTVHCPTE THQALTALAR
ESGATLFMVV QAATVALLSR SGAGTDIPVG SLVAGRTDEA LEDLVGFFVN TLVLRTDAGG
DPTFRELLDR VRETDLAAWA HQDLPFDRLV EALNPERSAA RHPLFQVMLT LAEAAEPAPA
LPGIRSETGQ PGLGIAKFDL TVNFYEHRDR AGHPNGLDIV LEYATDLYDP ATIETAADRL
TRVLDAVIAD PDVRVADIEL LTTAQRRALL DDYNDTSAAL PEGALHELFA AQAVRTPDAV
ALVCGDRELS YRELDRASDA FARLLAGRGV APGAAVGLFL DRSPEYVVAA LGILKAGGAY
VPLDARQPAE RLAFILADTG AALLVTDRGA PAQGLTLLPP PDVRAVPDDN AEAVQVPVHP
DQLAYVMYTS GSSGTPKGVA NTHRNVVELA LDPWWGVEGR HARVLAYSPL AFDSSTYELW
VPLLSGGTAI VLPAPKLDIA ELASAITEHR ATAVYFTTAL FDAMASEAVG ALAGLREIWT
GGDVLSAPAL RRVLEECPET TVVHAYGPTE STVFCSYQVF GPQERSVERL HLGVPMANTR
MYVLDEGLRP VVPGVVGELY VAGSHLAWGY VGRPGLSSER FVADPFGPAG ERMYRTGDLA
RWNEHGEVVF EGRADQQVKL RGFRIELGEI ETVLVAHASV SQAAVIVRED RPGDKRLVAY
VVAAGDGRVD TDALHRHGGA ALPEYMVPAA FVELDLLPLT ANGKLDRRAL PEPRLGTGPG
GRQGRTPVEE VLCGLFADAL GLPAVSIDDD FFRLGGHSLL ATRLVSRIRR TLGSQVSVRD
MFRHPTVARL ALFLADTGDT DRRPALVAGE RPERVPLSAA QRRLWFLDQM EGPSATYNIP
LAVRLTGTLD ADALHLALGD VVARHEALRT VFPADQGTPY QQILPAEDAR PTLALIPATR
EALPAVLRDL SATTFDLARE LPVRADLVQV GDDEHVLLLV THHIASDGWS NTPLVRDLAA
AYTARVAGAA PGWEPLPVQY ADYALWQQAL LAADEERQLD HWRRVLAGLP DEVTLPADRA
RPATASYRGA SLTVRCPAGL HASLTALARE SGTTLFMVAQ AATAALLARS GAGSDIPIGS
PVAGRGEEAL EDLVGFFVNT LVLRTDVSGN PTFRELLDRV RETDLAAWAH QDVPFDRLVE
DLNPERSAAR HPLFQVMLSV TDAAGPVPEL PGLRAESEFT DLDIAKFDLT FTFHEHRAPD
GGPAGLGITV EYATDLYDPA TVSAVTARLV RLLGAAADTP DVPVGALDVL ADDERTRLLD
TWHGTPRSTP AAALPQLFAE QAARTPDAVA LSHGTQRLTY AELDRRANRL ANRLIAEGVR
PGSRVALFQE RSPEAVVAIL AVVKAGAVYV PLDTRYPKDR IDLVVRMSGA RVFLTDRDLT
GFELPDGARA LSVTDPAGSA PDTAPEVTVH PDQLAYVMFT SGSTGVPKGV AVTHRNVTEL
AADNRFTGGA HRRVLLHSPL AFDATTYELW VPLLSGGTLV VAPPGLLDTA ALTRVLTEEA
ITGLWLTVGL FRLVAEEDPA AFAGLREVWT GGDVVPPEAV RRVMDVCPGL QVVNGYGPTE
TTTFATSHLL HRPFDYTGAL PIGRPLDNTR LYVLDEHLEL VAPGVPGELY IAGTGLAQGY
LDRPALTAER FVADPYGPAG SRMYRTGDLV RWSRDGEIEY LGRADQQVKL RGFRIEPGEI
ESALAAHASV AQAAVIVRED RPGDKRLVAY VVGNGDTPVD LDALHVHASE RLPDYMVPAA
FMPLDALPLT VNGKIDKRAL PQPPVSAGSG GRAPRNPREE VLCGLFAEVL GLPSVSVDDD
FFRLGGHSLL ATRLVSRIRT VLGAELPVPA LFENPNVARL AERLDRAESA RPKLRPMRRM
GASQ
//
