ID A0A1Q5KQF6_9ACTN Unreviewed; 732 AA.
AC A0A1Q5KQF6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Restriction endonuclease subunit M {ECO:0000313|EMBL:OKJ83803.1};
GN ORFNames=AMK31_16760 {ECO:0000313|EMBL:OKJ83803.1};
OS Streptomyces sp. TSRI0107.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703942 {ECO:0000313|EMBL:OKJ83803.1, ECO:0000313|Proteomes:UP000185813};
RN [1] {ECO:0000313|EMBL:OKJ83803.1, ECO:0000313|Proteomes:UP000185813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0107 {ECO:0000313|EMBL:OKJ83803.1,
RC ECO:0000313|Proteomes:UP000185813};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ83803.1}.
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DR EMBL; LIVZ01000006; OKJ83803.1; -; Genomic_DNA.
DR RefSeq; WP_073941380.1; NZ_LIVZ01000006.1.
DR AlphaFoldDB; A0A1Q5KQF6; -.
DR STRING; 1703942.AMK31_16760; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000185813; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endonuclease {ECO:0000313|EMBL:OKJ83803.1};
KW Hydrolase {ECO:0000313|EMBL:OKJ83803.1};
KW Nuclease {ECO:0000313|EMBL:OKJ83803.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185813};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747}.
FT DOMAIN 225..452
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 131..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 78173 MW; 0B846F536BD13581 CRC64;
MQDNATEVTA AGIARLAGVG RAAVSNWRRR HADFPKPVGG TETSPSFALA EVEAWLRHQG
KLAEVPLRER VWQQLAGHPE GPVTALTHAG SVLLLIHDRP TVWLEVSAGS DERLAAMLPA
ALEQVITPRF GEAARGRRPG QVNAGASVTT PPSVHTPSSV HRPLSVHTPP SVHTPSTNDR
PGDPTKTVKS ALAVHVPSGP ELLPSAPLLR GAAELAAEMG ARQTFEFLLG RHLDANPRQY
TLTPAELARL MADLAGPART VLDPACGTGA LLRAVPARPD QELYAQDSAA DLAALTAFRL
ALHTPAAVRA ADGDSLRADA HPALRADVVL CHPPFNERNW GHDELAYDPR WEYGFPARTE
SELAWVQHAL ARLRDGGTAV LLMPPAAASR RSGRRIRADL LRRGALRAVV ALPVGAAPPY
NIPLHVWVLR RPDKAPAQPE VLLADAGQFA TEGRGGPDWQ AVRDAVLDAW RAFDRAGTLA
ERPGLARSVP VIELLDDDVD FSPARHLPPP AAADGAEQLT DVRTRLGETL RLTTELTPPP
ARSAEPARWP LTTVGELARG GALVMRTGGN GGHTRVPVLT DHDVLAGTAP SGSLPESEDE
AVLTEPGDVV VPVLGGGAVA RVIDDATGGA ALGRNLVLLR PDPTALDPWF LAGFLRGTAN
NRQASSYAST ATRLDVRRLQ LPRLPLDEQR RYGARFRALD EFERALRHAS RLGEQLVRGM
YDGLTDGTVT PD
//
