ID A0A1Q5KW64_9ACTN Unreviewed; 1110 AA.
AC A0A1Q5KW64;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:OKJ85787.1};
GN ORFNames=AMK32_00035 {ECO:0000313|EMBL:OKJ85787.1};
OS Streptomyces sp. CB01883.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703943 {ECO:0000313|EMBL:OKJ85787.1, ECO:0000313|Proteomes:UP000186398};
RN [1] {ECO:0000313|EMBL:OKJ85787.1, ECO:0000313|Proteomes:UP000186398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB01883 {ECO:0000313|EMBL:OKJ85787.1,
RC ECO:0000313|Proteomes:UP000186398};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ85787.1}.
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DR EMBL; LIWA01000001; OKJ85787.1; -; Genomic_DNA.
DR RefSeq; WP_073886933.1; NZ_LIWA01000001.1.
DR AlphaFoldDB; A0A1Q5KW64; -.
DR OrthoDB; 499349at2; -.
DR Proteomes; UP000186398; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000186398};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..90
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..90
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 236..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 118834 MW; D10751C12FA843A6 CRC64;
MRYRILGPTQ AIDDRGIPLP VGGRRLRTLL AVLALRAGRT STPDTLIDEI WADDPPQDAP
AALQALVGRL RRTLGRQAIA SAPGGYRLEA TEEDVDLHVF ERLAHTGTKA LADGDPATAH
RTLTRALALW HGPALADLPD RTAATRPEAL RLEATRARAA AALDLGRAQD AVPELRELTT
AHPYDEPLHA LLIRALRDTG RGADALTAYE SARRTLADAL GTDPGPELTA LHASLLEQPG
PRPGHRPPKP AAAPPPAQPP ERTGNLRPRL TSFVGREPEL KAIRSDLHRA RLVTLTGPGG
SGKTRLAEEA AAGLSQAWLV ELAPLDHPEA VPGAVVSALG LRETVLLAND LATGPADPTA
QLIEYCAPRS RLLILDNCEH VVDAAAALAE TLLTHCPGLT ILATSREPLG VPGESVRPVE
PLVPEQAHRL FTERAQAVRP DAGAVLADTD AVGEICRRLD GLPLAIELAA ARLRLLTPRQ
IADRLDDRFR LLTTGSRTVL PRQQTLRAVV DWSWELLDER ERTVLREVSV FAGGWDLAAA
EAVCTGPAAD LIGALVDKSL VVAAPHGPAD GGPGTGMRYR MLETIHEYAT ERAAEVPGLR
AAAERRHRAW VRALVREAEP LLRSAEQLPW ISRLETELDN IRAALDRAVR AGDEAEAGAI
CLSMGWFWWL RNYRQEAVAR VRGVLRLGVA LDGAPASASG SELTARAESA DPVGAFLAAP
EGESGHPLRE LRMDLRMLDL FLTSESSADN LATDERAAEY IARVRAAYEH GGPQSARLPG
IVWPLTSYYL GGPADVGPDM TASVANCRTY GGDWEIGVAL MYRAHVAVDS PGNLRGVDED
LAELRVLSRR VGDRWMRAQV CSAAGEAAMA RGRFDEAGTE YEEALRLAYE VGAYAESPFL
MARLAEIAYR SGDRDTALAT LEEAGAAADR YAVPESRAFA LLMRAHIALH DGLPGQAREL
YEATLAVIRG GTPPPQFVAA LRTVDALVTA AESGPEQGLP VVADALREAV AQRCAESITA
GLVDIGAGLL ARLGDLPGAL RLFAAADHWR DGRPRPEPER GEAARVHADA RAVLPAERFA
AECARGAALD VADVLRELDE RAAAVAPDRR
//
