ID A0A1Q5L386_9ACTN Unreviewed; 492 AA.
AC A0A1Q5L386;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Acyl-CoA synthetase {ECO:0000313|EMBL:OKJ88327.1};
GN ORFNames=AMK31_07320 {ECO:0000313|EMBL:OKJ88327.1};
OS Streptomyces sp. TSRI0107.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703942 {ECO:0000313|EMBL:OKJ88327.1, ECO:0000313|Proteomes:UP000185813};
RN [1] {ECO:0000313|EMBL:OKJ88327.1, ECO:0000313|Proteomes:UP000185813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0107 {ECO:0000313|EMBL:OKJ88327.1,
RC ECO:0000313|Proteomes:UP000185813};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ88327.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LIVZ01000003; OKJ88327.1; -; Genomic_DNA.
DR RefSeq; WP_073939591.1; NZ_LIVZ01000003.1.
DR AlphaFoldDB; A0A1Q5L386; -.
DR STRING; 1703942.AMK31_07320; -.
DR OrthoDB; 5240965at2; -.
DR Proteomes; UP000185813; Unassembled WGS sequence.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43201:SF5; MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000185813}.
FT DOMAIN 6..349
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 468..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 51470 MW; E3B49C9CD96A744F CRC64;
MLDTLAHALR RHPDRPAVLG TTRSGAERTR ATYGDLADLA DRYTTALHAR GVARGGTVGV
AVRPGPRALP VMLAVHGLGA RAAVLDPGAG PDVLRARLAL ARPDLVLADA TAQAVAGWAR
PLARAARLAL PDLAMLGPVA TVGPRMPGCA PALDADVRSV VLPRPVDGDG DAVIVFTSGT
TSRPRAVVHT RSSLAAGMAT VADLVRPEAG RPVLGGTFFV LVPSLASGAP VALPARSTRV
LARQLRRLAP QCTYLTPPQL RRLLAEGGRF TGRVWTGSAP ASSELLTRVK RAGADEAWGV
YALTELFPAA AVEQADKAAF TGDGDLVGAP LPGVTAKTDS DGELLLSGPA ARDRYLGEDP
DPWVATGDRA RLDGGRIVLE GRRKDMILRR AENIYPGLYE PALHVPGVEL ALLVGVPDDD
GDERLVAVVQ PAAKADRAAL RSALAEPLER MGAARPDAVL LADIPLSGRS RKPDRAATAR
LAARRLAERS RR
//
