ID A0A1Q5L3S6_9ACTN Unreviewed; 426 AA.
AC A0A1Q5L3S6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:OKJ88480.1};
DE EC=2.3.1.179 {ECO:0000313|EMBL:OKJ88480.1};
GN ORFNames=AMK31_08335 {ECO:0000313|EMBL:OKJ88480.1};
OS Streptomyces sp. TSRI0107.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703942 {ECO:0000313|EMBL:OKJ88480.1, ECO:0000313|Proteomes:UP000185813};
RN [1] {ECO:0000313|EMBL:OKJ88480.1, ECO:0000313|Proteomes:UP000185813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0107 {ECO:0000313|EMBL:OKJ88480.1,
RC ECO:0000313|Proteomes:UP000185813};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ88480.1}.
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DR EMBL; LIVZ01000003; OKJ88480.1; -; Genomic_DNA.
DR RefSeq; WP_073939755.1; NZ_LIVZ01000003.1.
DR AlphaFoldDB; A0A1Q5L3S6; -.
DR STRING; 1703942.AMK31_08335; -.
DR Proteomes; UP000185813; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:OKJ88480.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185813};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:OKJ88480.1}.
FT DOMAIN 11..424
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 426 AA; 42628 MW; B3E088780F6C05DE CRC64;
MRHPHDPAPG NAVAAITGLG ATTALGGDVP STWTALLAGK CGIDRIEIGP PNGPARVHLA
ATAAVDPRSV LSPAKAAHCD RSAQLALVAA QEALRDAGLP KRPELAAAGT RVAATVGVGL
GGLGTIVEQN RRLEEGGPDR VAPRTIPMML PNHPAAEVGL MVGAKAGVHA PVSACAAGAE
ALAQALAMIR AGHADLVVAG GTESALVPVA FAGFARLQAL SRRHDEPKRA SRPFDADRDG
FVMGEGAGIL VLESVAHAAA RGARVYGYLT GAGITNDSHH VAQPAPGGTG CAAAITAALE
DAALPPDEVR HINAHATSTP LGDLGEAQAL RGVFGAALDD VPVSAIKAAL GHTLGAAGAI
EAVMTVLALR ERTAPPDCTL ERLDPAIELN VVGPEPVPLP SGPLAAVSTS MGFGGHNVAL
AFRTAS
//
