ID A0A1Q5L7K4_9ACTN Unreviewed; 566 AA.
AC A0A1Q5L7K4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:OKJ90313.1};
GN ORFNames=AMK31_00710 {ECO:0000313|EMBL:OKJ90313.1};
OS Streptomyces sp. TSRI0107.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703942 {ECO:0000313|EMBL:OKJ90313.1, ECO:0000313|Proteomes:UP000185813};
RN [1] {ECO:0000313|EMBL:OKJ90313.1, ECO:0000313|Proteomes:UP000185813}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSRI0107 {ECO:0000313|EMBL:OKJ90313.1,
RC ECO:0000313|Proteomes:UP000185813};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ90313.1}.
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DR EMBL; LIVZ01000001; OKJ90313.1; -; Genomic_DNA.
DR RefSeq; WP_073938292.1; NZ_LIVZ01000001.1.
DR AlphaFoldDB; A0A1Q5L7K4; -.
DR STRING; 1703942.AMK31_00710; -.
DR OrthoDB; 9805696at2; -.
DR Proteomes; UP000185813; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd00268; DEADc; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:OKJ90313.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000185813}.
FT DOMAIN 39..67
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 70..243
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 254..415
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 39..67
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 447..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 58845 MW; 908907A614953313 CRC64;
MSRRPQKSNR RASSPPPSAS SPREFRLPEG TTPALPAVEE FAALDMPAGL LQTLTAQGVT
TPFPIQAATL PNSLAGRDLL GRGRTGSGKT LAFGLALLAR TAGLRAEPKA PLALVLVPTR
ELAQQVTDAL TPYATAVNVR LATVVGGLSI TKQAGALRRG TEVLVATPGR LNDLVERGDC
VLDDVRITVL DEADQMTDMG FLPQITKLIQ RVRPDGQRML FSATLDRNID RLVQRFLTDP
VVHSVDPSAG AVTTMEHHVL HVQDETDKKA VTTRIAARDG RVILFLDTKR SADRLAKRLL
AVGVRAAALH GGRSQPQRNR TLEQFKNGQV TALVATNVAA RGIHVDDLDL VVNVDPPTDH
KDYLHRGGRT ARAGGSGSVV TLVLPDQKRD VTRLMSDAGI RPRATRVASS DAELATITGA
REPSGVAVTI EVPQQATTPK ASRPDGKPGG KPGRRSGRRR GNAEGAETAS RTATRKTAGA
TPSGDSPSRS SGGTSATGGR GSARRTGSGG ATGAASAGTG GRGSDRRSGA RAANGTASGK
AARGSARRKP ANGATGGATG TRGGTR
//
