ID   A0A1Q5L9Q0_9ACTN        Unreviewed;      1048 AA.
AC   A0A1Q5L9Q0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Amidohydrolase {ECO:0000313|EMBL:OKJ91046.1};
GN   ORFNames=AMK33_35880 {ECO:0000313|EMBL:OKJ91046.1};
OS   Streptomyces sp. CB02400.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKJ91046.1, ECO:0000313|Proteomes:UP000185993};
RN   [1] {ECO:0000313|EMBL:OKJ91046.1, ECO:0000313|Proteomes:UP000185993}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02400 {ECO:0000313|EMBL:OKJ91046.1,
RC   ECO:0000313|Proteomes:UP000185993};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKJ91046.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LIWB01000024; OKJ91046.1; -; Genomic_DNA.
DR   RefSeq; WP_073937381.1; NZ_LIWB01000024.1.
DR   AlphaFoldDB; A0A1Q5L9Q0; -.
DR   Proteomes; UP000185993; Unassembled WGS sequence.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR011659; PD40.
DR   InterPro; IPR006311; TAT_signal.
DR   PANTHER; PTHR43135; ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR43135:SF3; ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE; 1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF07676; PD40; 5.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS51318; TAT; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:OKJ91046.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185993}.
FT   DOMAIN          675..996
FT                   /note="Amidohydrolase-related"
FT                   /evidence="ECO:0000259|Pfam:PF01979"
SQ   SEQUENCE   1048 AA;  111610 MW;  25CAE788342D50FA CRC64;
     MSSGSVSRRG FLGVSAAGLT GALSPVATRA EAASAAGEDQ VLRYEEMTGG SVTASRDGKL
     LIAEVQGVLW RVPRGGGAAT RLTDWELEAT APALSPDGGT VALCGYRDGT FHLWTMGADG
     SGLRRLTDGP WDDRGPAWSP DGTRLVFSSE RGGDAVAGSA FGLWVLDVRD GRVRRLTGGD
     FEDLDAAWCP DGRSVVCVRA AHTPDGASDG GRALVRVPAA GGEARVVHSV GSGRLLCPSV
     SPAGRIACLR LSGTGSSPSL PAAKAVLMVD GRVVTDDEDL AAAPPCWLDE DRLLYVADGR
     IRIRTLDSSA PVEEVAFTAR MPMPRPRRRV GPRNRYPARP VPVRGIHLPA LSPDGGSVAF
     VALNALWLMD VGGAPRKLVQ ASPVHHLQMP VWAPDGRTLL YCTDRDGLTA VRRLRPDDGH
     DEPVTGQGRL CPALSPDGTL LACQDVTGNL LLRTLATGAE RVLARPMATD GPPGAPTWSP
     DGRYVAFCDR NRLNHRFREG YHLIRVVDTR TGAERRHLPA DHQSLADRAA AGPVWSPDGR
     WMALIAESAL HLLPVTADGT PAGPVRRLTD EPADHACWAG DSATLLYLSS GRLRLLSLDE
     ERVPSRTRTL PVLLTTGQRP RHEPLRVHAG RLWDGTGTTV RQDVDILVEG GRITTVEPHR
     ARRPGHRTLD ASDHTVVPGL FDSHTHPYTA TYGARQHLAA LAYGITTTAC MGAPLYEAVR
     LRESLAAGHS TGPRMLACAE LIDGPRTAYA KGRAHRTHAG LRRTLERVTA LDADFVKTYV
     RAPGRAMAEA AEAAHRLGVP CGSHLCSPGR AAGQDLTTHL QATQRLAYGH ATTPTGHLHQ
     DLLEQYADGS FALIATPFTA QALLGADPAL ADDPRVLALL PPWDVAAVQE RAKTEPTAEQ
     RRALAIEMGN YRRLAAHGAT LALGTDSPLV PVGLSLHLAL RALVAHGFTP VQALRTVTTT
     PARLFGLDAD LGTVEPGRIA DLTVVDGDPF TDFAALVDIP LVLRDGVPHR QADLTATHRQ
     APAPAPRNTT WLEVAHTLHR NSCCHSGD
//