ID A0A1Q5LD05_9ACTN Unreviewed; 240 AA.
AC A0A1Q5LD05;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Type-5 uracil-DNA glycosylase {ECO:0000256|ARBA:ARBA00023887};
GN ORFNames=AMK33_31245 {ECO:0000313|EMBL:OKJ94759.1};
OS Streptomyces sp. CB02400.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKJ94759.1, ECO:0000313|Proteomes:UP000185993};
RN [1] {ECO:0000313|EMBL:OKJ94759.1, ECO:0000313|Proteomes:UP000185993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02400 {ECO:0000313|EMBL:OKJ94759.1,
RC ECO:0000313|Proteomes:UP000185993};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the uracil-DNA glycosylase (UDG) superfamily.
CC Type 5 (UDGb) family. {ECO:0000256|ARBA:ARBA00023779}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ94759.1}.
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DR EMBL; LIWB01000018; OKJ94759.1; -; Genomic_DNA.
DR RefSeq; WP_073936487.1; NZ_LIWB01000018.1.
DR AlphaFoldDB; A0A1Q5LD05; -.
DR Proteomes; UP000185993; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0033958; F:DNA-deoxyinosine glycosylase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd10031; UDG-F5_TTUDGB_like; 1.
DR Gene3D; 3.40.470.10; Uracil-DNA glycosylase-like domain; 1.
DR InterPro; IPR044147; UdgB-like.
DR InterPro; IPR005122; Uracil-DNA_glycosylase-like.
DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf.
DR PANTHER; PTHR33693; TYPE-5 URACIL-DNA GLYCOSYLASE; 1.
DR PANTHER; PTHR33693:SF3; TYPE-5 URACIL-DNA GLYCOSYLASE; 1.
DR Pfam; PF03167; UDG; 1.
DR SMART; SM00986; UDG; 1.
DR SMART; SM00987; UreE_C; 1.
DR SUPFAM; SSF52141; Uracil-DNA glycosylase-like; 1.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000185993}.
FT DOMAIN 48..225
FT /note="Uracil-DNA glycosylase-like"
FT /evidence="ECO:0000259|SMART:SM00986"
SQ SEQUENCE 240 AA; 25932 MW; 10DB4B7BF09F9F51 CRC64;
MDPRGLDRLD QRIAGCRACP RLVDWREEVA RTKRAAFADW TYWGRPVPGF GPADARLLIV
GLAPAAHGGN RTGRMFTGDR SGDVLYQALY DVGLASQPGS THAGDGLELY GVRVTSPVHC
APPANKPTPE ERDTCRPWLV RELRLLRPTV RAALVLGAFG WQAALPAFAE AGWTVPRPRP
AFAHGAHVTL DAPDGPGLHL FGCFHVSQRN TFTGRLTPEM LRDVLRTAAG AAGLSTRGRG
//
