ID A0A1Q5LGE0_9ACTN Unreviewed; 575 AA.
AC A0A1Q5LGE0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Type-I PKS {ECO:0000313|EMBL:OKJ97273.1};
DE Flags: Fragment;
GN ORFNames=AMK33_30350 {ECO:0000313|EMBL:OKJ97273.1};
OS Streptomyces sp. CB02400.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKJ97273.1, ECO:0000313|Proteomes:UP000185993};
RN [1] {ECO:0000313|EMBL:OKJ97273.1, ECO:0000313|Proteomes:UP000185993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02400 {ECO:0000313|EMBL:OKJ97273.1,
RC ECO:0000313|Proteomes:UP000185993};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKJ97273.1}.
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DR EMBL; LIWB01000016; OKJ97273.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5LGE0; -.
DR Proteomes; UP000185993; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000185993};
KW Transferase {ECO:0000256|ARBA:ARBA00023315}.
FT DOMAIN 31..455
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 575
FT /evidence="ECO:0000313|EMBL:OKJ97273.1"
SQ SEQUENCE 575 AA; 60284 MW; 4FDCBBF594F35E1B CRC64;
MSTPSSDRME AALPAIRLLQ KRAADLEAQR TEPIAVVSMA CRLPGGIGTP EAFWDLLSRG
GDAVGGLPKR WEGLGLYDPD PEAVGKSYAR EGGFLEDIEG FDAEFFGISP REAQSMDPQQ
RIVLETAWEA LERAGIRPGT LNESRTGVYL GTMGSDYDAL THYDLDALDG YVSSGNASSV
LSGRVSYALG LQGPAVTVDT ACSSSLVALH LAVSALRTRE CGLALAGGVT VMSTPSTFVE
FSRLKGLSAD GRCKSFSADA NGVGWAEGAG MLVLKRLSDA ERDGDRVLAV IRGSAVNQDG
RSQGLTAPNG PSQQRVVQDA LAAARLTPDD IDAIEAHGTG TTLGDPIEAG ALAEVFGPTR
AQDHPLYLGS SKSNIGHAQA AAGAIGVIKT VLALQHETLP KTLHADEPSP HIEWEGSGLE
LLQEARPWVR GERVRRAGVS SFGLSGTNAH VVIEEAPAVE AAVASEAPEL PVPVVVSGRS
EAALREQAGR WANWLEVHDE VPLVDVATTA ALHRTHFDSR AAVLAASPDE ATAGLRAIAE
GQPHEQAVTG TAQPRGKTVF VYPGQGSQWV GMGHD
//
