ID A0A1Q5LYP5_9ACTN Unreviewed; 359 AA.
AC A0A1Q5LYP5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=FMNH2-dependent monooxygenase {ECO:0000313|EMBL:OKK07048.1};
GN ORFNames=AMK09_36445 {ECO:0000313|EMBL:OKK07048.1};
OS Streptomyces sp. CB02488.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK07048.1, ECO:0000313|Proteomes:UP000186200};
RN [1] {ECO:0000313|EMBL:OKK07048.1, ECO:0000313|Proteomes:UP000186200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02488 {ECO:0000313|EMBL:OKK07048.1,
RC ECO:0000313|Proteomes:UP000186200};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the NtaA/SnaA/DszA monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00033748}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK07048.1}.
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DR EMBL; LIVO01000023; OKK07048.1; -; Genomic_DNA.
DR RefSeq; WP_073739309.1; NZ_LIVO01000023.1.
DR AlphaFoldDB; A0A1Q5LYP5; -.
DR STRING; 1703920.AMK09_36445; -.
DR OrthoDB; 3265338at2; -.
DR Proteomes; UP000186200; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 3.20.20.30; Luciferase-like domain; 1.
DR InterPro; IPR011251; Luciferase-like_dom.
DR InterPro; IPR036661; Luciferase-like_sf.
DR InterPro; IPR016215; NTA_MOA.
DR PANTHER; PTHR30011; ALKANESULFONATE MONOOXYGENASE-RELATED; 1.
DR PANTHER; PTHR30011:SF16; C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED; 1.
DR Pfam; PF00296; Bac_luciferase; 1.
DR PIRSF; PIRSF000337; NTA_MOA; 2.
DR SUPFAM; SSF51679; Bacterial luciferase-like; 1.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000337-1};
KW FMN {ECO:0000256|PIRSR:PIRSR000337-1};
KW Monooxygenase {ECO:0000313|EMBL:OKK07048.1};
KW Oxidoreductase {ECO:0000313|EMBL:OKK07048.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186200}.
FT DOMAIN 20..255
FT /note="Luciferase-like"
FT /evidence="ECO:0000259|Pfam:PF00296"
FT BINDING 43
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000256|PIRSR:PIRSR000337-1"
FT BINDING 71
FT /ligand="FMN"
FT /ligand_id="ChEBI:CHEBI:58210"
FT /evidence="ECO:0000256|PIRSR:PIRSR000337-1"
SQ SEQUENCE 359 AA; 38980 MW; CAE2D6FB07350B95 CRC64;
MPPIRPLHLA AEIGGPPRYE PEHYTALARL AEQGALDFVT LGDSFARPGP DALAVLSRVA
PATRRIGLVP TVTTTHTEPF HVSSAVATLD WVSRGRAGWQ ADVSTTGAEA RLFGRRPAAP
AAELWREAGE VADVGARLWD SWEDDAEIRD TATGRFVDRD KLHYVDFEGA TFRVRGPAIV
PRPPQGRPVV VIDGTAEPAR QTAARHADVV LVRATTPERT ARIRDDVRRR AEAHGRHPDT
LRVLAALTVD LGDAESAPEP GLASGPPLAA HGTYYRGGPV DLADLIGRWH RAGAVDGFHL
TPITPGRDLE RIVNGTVALL QHRSLFRTFH PGGTLREHLG LARPANRYAR DHVLRGERA
//
