ID A0A1Q5LZX3_9ACTN Unreviewed; 386 AA.
AC A0A1Q5LZX3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:OKK07486.1};
GN ORFNames=AMK09_36000 {ECO:0000313|EMBL:OKK07486.1};
OS Streptomyces sp. CB02488.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK07486.1, ECO:0000313|Proteomes:UP000186200};
RN [1] {ECO:0000313|EMBL:OKK07486.1, ECO:0000313|Proteomes:UP000186200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02488 {ECO:0000313|EMBL:OKK07486.1,
RC ECO:0000313|Proteomes:UP000186200};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK07486.1}.
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DR EMBL; LIVO01000022; OKK07486.1; -; Genomic_DNA.
DR RefSeq; WP_073739229.1; NZ_LIVO01000022.1.
DR AlphaFoldDB; A0A1Q5LZX3; -.
DR STRING; 1703920.AMK09_36000; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000186200; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000186200};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:OKK07486.1}.
FT DOMAIN 5..256
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 264..385
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 342
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 372
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 386 AA; 39742 MW; 7B8EE50E522FA248 CRC64;
MTEAVIVEAA RTPVGRRRGV LSGLHPAELL GLAQKGLVER AGIAPGTVDQ VIGGCVTQAG
EQSNNVTRGA WLHSGLPHTT ACTTIDCACG SSQQAVHLVA GLIAAGAIET GIGCGVESMS
RVFLGAALTP GKGSPVPDSW SLDMPDQFTA AERIARNRGI TRADADALGL ASQQKAARAW
SEGRFDSQII EVDAPVTGPA GPTGETVTVT RDQGLRDTTA EALAALSPVL PDGIHTAGNS
SQISDGAAAV LLMSRERAAR EGLRPRARIL ASAMVGSEPY YHLDGPVAAT ERVLRTAGMT
LDDIDLVEIN EAFASVVLSW ARVHRADLDK VNVNGGAIAL GHAVGSTGAR LVTQALHELE
RTGKSTALIT MCAGGAHATA TVIERI
//
