ID A0A1Q5M7S4_9ACTN Unreviewed; 669 AA.
AC A0A1Q5M7S4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Copper resistance protein CopC {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMK33_15160 {ECO:0000313|EMBL:OKK10267.1};
OS Streptomyces sp. CB02400.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKK10267.1, ECO:0000313|Proteomes:UP000185993};
RN [1] {ECO:0000313|EMBL:OKK10267.1, ECO:0000313|Proteomes:UP000185993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02400 {ECO:0000313|EMBL:OKK10267.1,
RC ECO:0000313|Proteomes:UP000185993};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK10267.1}.
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DR EMBL; LIWB01000005; OKK10267.1; -; Genomic_DNA.
DR RefSeq; WP_073933381.1; NZ_LIWB01000005.1.
DR AlphaFoldDB; A0A1Q5M7S4; -.
DR Proteomes; UP000185993; Unassembled WGS sequence.
DR GO; GO:0042597; C:periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR GO; GO:0046688; P:response to copper ion; IEA:InterPro.
DR Gene3D; 2.60.40.1220; -; 1.
DR InterPro; IPR032694; CopC/D.
DR InterPro; IPR007348; CopC_dom.
DR InterPro; IPR008457; Cu-R_CopD_dom.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR34820; INNER MEMBRANE PROTEIN YEBZ; 1.
DR PANTHER; PTHR34820:SF4; INNER MEMBRANE PROTEIN YEBZ; 1.
DR Pfam; PF04234; CopC; 1.
DR Pfam; PF05425; CopD; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000185993};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..669
FT /note="Copper resistance protein CopC"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013316199"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..127
FT /note="CopC"
FT /evidence="ECO:0000259|Pfam:PF04234"
FT DOMAIN 341..416
FT /note="Copper resistance protein D"
FT /evidence="ECO:0000259|Pfam:PF05425"
FT REGION 410..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 68642 MW; CC62083D14DE28C5 CRC64;
MTQTIAPRVR ILVLLLLAVT GALLAGAAPA SAHAALTGSD PGQGAVVDTA PTQVSLTFSE
QIAVSDDAVR VLDPKGKRVD KGDPANLSGT TYTVRLLSGL PDGTYTVAYQ VVSADSHPVA
GAFTFSIGAP SETSVSACAQ ASDDGLVGWL YDIGRYVSYA GFVVMAGGAA FVLACWGRGA
GVRAVQRLVV SGWLALTAAT LALLLLRGSY TTSGKVGDVF DLSLLGDVLQ TKTGAALVSR
LLLLAAAALF IAVLFGAYDK RDAEEKRDLT FGLAIGGTVV AAGLAASWAM SEHASQGLQP
GIAMPVDVLH LLAVAAWLGG LTALLVALYR APADTPVGQD AVQRFSRLAF GSVVTLVVTG
VYQSWRQLGS WSALTDTRYG QLLLAKIGLV VVMVAIASVS RRWTARLAEA PAPAAREEEE
ERGKEKQPAG AGKATGAGKG ESGNGESGKG ESGNGESGKG ESGKGESGSG KGGDARAAQL
ARQRAAMESA RQKRLRDADP NRFGLRRSVL AEAGIAVVLL AVTTVLTQTE PGRTEQEAAA
ATSASSSSSA PTGQGTGAVT LNMPFDTGGE NGKGVVTVDL DPARVGDNDM HIYVEGPDGQ
AFDIPEVKVA FTLSAKGIGP LPVVPDHITT GHWSASGVQI PMTGDWKVEV TVRTSDIDQV
TVSKNTKIG
//
