ID   A0A1Q5MF35_9ACTN        Unreviewed;       404 AA.
AC   A0A1Q5MF35;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=ROK family transcriptional regulator {ECO:0000313|EMBL:OKK12808.1};
GN   ORFNames=AMK33_06800 {ECO:0000313|EMBL:OKK12808.1};
OS   Streptomyces sp. CB02400.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKK12808.1, ECO:0000313|Proteomes:UP000185993};
RN   [1] {ECO:0000313|EMBL:OKK12808.1, ECO:0000313|Proteomes:UP000185993}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02400 {ECO:0000313|EMBL:OKK12808.1,
RC   ECO:0000313|Proteomes:UP000185993};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family.
CC       {ECO:0000256|ARBA:ARBA00006479}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKK12808.1}.
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DR   EMBL; LIWB01000002; OKK12808.1; -; Genomic_DNA.
DR   RefSeq; WP_073932071.1; NZ_LIWB01000002.1.
DR   AlphaFoldDB; A0A1Q5MF35; -.
DR   Proteomes; UP000185993; Unassembled WGS sequence.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF12802; MarR_2; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000185993}.
FT   DOMAIN          21..61
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000259|Pfam:PF12802"
SQ   SEQUENCE   404 AA;  42370 MW;  E2DEBEF42E51DB14 CRC64;
     MAGTAGTPGT PRVLRAMNDR TALDLLLEHG PLSRTRIGKL TGLSKPTASQ LLARLEAGGL
     VLATGTTEGR PGPGAQLYEV NPAAAYAAGL DVNPRRIRAA VADVTGRTVG RHELPAPGRR
     SGVPVVQQVT DALDGAVKAA GLSRADIHRL VIGTPGAFDP NTGRLRYASH LPGWHSPTLL
     DELAAALPMP FEYENDVNLV ALAEQRLGAA RSHSDFVLLW NQEGLGAALV LGGRLHRGWT
     GGAGEVGFLP VPGTPLVRQV TKANSGGFQE LAGSQAVPRL ARELGIEDIP QDPYPEAAAT
     LLTRAAAAPD DDRLHRLLRT YATRLATGLA SLVSVLDPEL VVLSGTGLTS GGEVLRTLIQ
     AELEELAASR PRLVVGDVHE HPVLRGALES ALATTRDEVF DTSR
//