ID A0A1Q5MGI4_9ACTN Unreviewed; 720 AA.
AC A0A1Q5MGI4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Kinase {ECO:0000313|EMBL:OKK13330.1};
GN ORFNames=AMK33_00305 {ECO:0000313|EMBL:OKK13330.1};
OS Streptomyces sp. CB02400.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703944 {ECO:0000313|EMBL:OKK13330.1, ECO:0000313|Proteomes:UP000185993};
RN [1] {ECO:0000313|EMBL:OKK13330.1, ECO:0000313|Proteomes:UP000185993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02400 {ECO:0000313|EMBL:OKK13330.1,
RC ECO:0000313|Proteomes:UP000185993};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK13330.1}.
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DR EMBL; LIWB01000001; OKK13330.1; -; Genomic_DNA.
DR RefSeq; WP_073930637.1; NZ_LIWB01000001.1.
DR AlphaFoldDB; A0A1Q5MGI4; -.
DR Proteomes; UP000185993; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OKK13330.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000185993};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OKK13330.1}.
FT DOMAIN 96..193
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 440..501
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 641..715
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 78037 MW; 73B8AFCE99C158DF CRC64;
MNAEAVNPAT PGPVTSGHVT PTGSRRKSRP RLDLRRLGRA ALLGPAARDR LPDAIGHVVD
AHRAHHPDAD LEPLRRAYLL AESSHRGQMR KSGEPYITHP LAVTLILAEL GAETTTLTAS
LLHDTVEDTE VTLDQVGEQF GEEVRYLVDG VTKLEKVDYG AAAEPETFRK MLVATGNDVR
VMSIKLADRL HNMRTLGVMR PEKQERIAKV TRDVLIPLAE RLGVQALKTE LEDLVFAILH
PEEYGHTREL IVRNAARADD PLAEVADDVR KVLREADITA EVLIRPRHFV SVHRVSRRRG
ALRGADFGRL LVLVNEDADC YGVLGELHTC MTPVVSEFKD FIAVPKFNLY QSLHTAVAGA
DGQVVEVLIR THQMHKVAEA GVVALGNPYA APPEEQSASD GERVDPTRPG WLSRLLDWQR
AAPDPDTFWS TLREDLAQDR EITVFRPDGG TLGLPEGATC VDAAYAQYGE DAHACIGARV
NGRLATLSTV LKDGDTVQLL MGQDAASEPS REWLEHAHTP AARIAIQRWL TAHPAQDEAS
GAVPEEAARP LTDDPAPSPA PDAPAPGRPT AAQVLADRAG ATVRLAGCCT PVPPDEVTGF
AVRGGAVTVH RVECAGVERM KSAGRAEVGV RWGEGAECRV TLVAESFVRP HLLADLTEAM
ALEGAEIVSA TVEPPDRQQV RHTYTVQLPD AAHLPVLMRA MRNVAGVYDV SRAQRQAPGV
//
