ID A0A1Q5MS00_9ACTN Unreviewed; 961 AA.
AC A0A1Q5MS00;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dimethylmenaquinone methyltransferase {ECO:0000313|EMBL:OKK16952.1};
GN ORFNames=AMK16_24650 {ECO:0000313|EMBL:OKK16952.1};
OS Streptomyces sp. CB00455.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK16952.1, ECO:0000313|Proteomes:UP000185643};
RN [1] {ECO:0000313|EMBL:OKK16952.1, ECO:0000313|Proteomes:UP000185643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK16952.1,
RC ECO:0000313|Proteomes:UP000185643};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK16952.1}.
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DR EMBL; LIVQ01000006; OKK16952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5MS00; -.
DR STRING; 1703927.AMK16_24650; -.
DR Proteomes; UP000185643; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF02754; CCG; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:OKK16952.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185643};
KW Transferase {ECO:0000313|EMBL:OKK16952.1}.
FT DOMAIN 39..254
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT REGION 678..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 100157 MW; 9E5187AA58B8CDD9 CRC64;
MDAVTSPGEL ERTLRAELRG EVDFGAAARA LVTMDASNYR RVPLGVVAPR DAEDVAAALR
VCAAAGVPVV PRGGGTSIAG QATGTGVVLD FTRHMNAVLS VDPAARTAVV QPGLVLDRLR
DAVRPYGLTF GPDPSTRSRC TLGGMIGNNA CGAHSVAWGT TADNVAELAV AAYGGAAHRI
STGWAGAPAG LSELVDGHLG LLRTGMPPEF SRRISGYDLQ SLLPERGVRL ARAFCGSEGT
LGVVTEAVVR LVEAPRAPVL AVLGYADETA AADAAAGLLP YGPLTVEGMA RDLVGDAAGL
PRGGAWLFVE MPDAGAALPL VRGADALDAL VVADPARQRA LWRIREDAAG TATRMPGGAA
GAGPGAESGA GAMAWPGWED CAVPPARLGA YLRAFRALLA EHGLHGSPYG HFGEGCVHVR
IDFDLVTREG VARFRTFSQE LAALVVDHGG SLSGEHGDGQ ARAELLPRMY GARVVRLFGA
YKDVWDPAGG MNPGILARPA RLDENLRFAV LPRTPFAQDV ARCVGVAKCR SHESGTAAVM
CPSYRVTGEE RHSTRGRARL LHEMLAGEVV TDGWRSSEVA GALDLCLGCK GCLSDCPVGV
DMAAHKAEFL HRHWAGRLRP LAHYTLGGLP AWLHLIARLR AARPVNALAR LFPAPGLTRE
RPLPQLAREP FSHWWRTRPA APGPSVPGRV SGGAGAADRA GAVGPGEAAG RGPGEAAVLG
SGPAAGNAPV VTLWPDTFTE YLAPEAGRAA VRVLEDAGLR VAVPRGPVCC GLTYVSTGRL
DRARTVLRRT LDAVDAQAGT PGPVLVLEPS CAAALRGDLP ALLPDDPRAR RLASAVRTFA
ETLEEYAPQW RPPRLDRSVA GQTHCHQHAV LGDAADRRLR ERAGLVGDLS GGCCGLAGNF
GFEPGHHEVS VACAEEQLLP SLRAAPGDAL VQADGYSCRT QIAQLGGVRA RHLAEILADG
L
//
