ID A0A1Q5MS94_9ACTN Unreviewed; 549 AA.
AC A0A1Q5MS94;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Histidine kinase {ECO:0000313|EMBL:OKK17154.1};
GN ORFNames=AMK09_20550 {ECO:0000313|EMBL:OKK17154.1};
OS Streptomyces sp. CB02488.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK17154.1, ECO:0000313|Proteomes:UP000186200};
RN [1] {ECO:0000313|EMBL:OKK17154.1, ECO:0000313|Proteomes:UP000186200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02488 {ECO:0000313|EMBL:OKK17154.1,
RC ECO:0000313|Proteomes:UP000186200};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK17154.1}.
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DR EMBL; LIVO01000008; OKK17154.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5MS94; -.
DR STRING; 1703920.AMK09_20550; -.
DR OrthoDB; 5241249at2; -.
DR Proteomes; UP000186200; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF56; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DOST; 1.
DR Pfam; PF13185; GAF_2; 2.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OKK17154.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186200};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 27..176
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 197..340
FT /note="GAF"
FT /evidence="ECO:0000259|SMART:SM00065"
FT DOMAIN 452..549
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 549 AA; 58074 MW; B9438CDE327F6640 CRC64;
MRGLSTELTA RVPQLLEAMR SVGTGLELHT TLDRICETAA ELAHARYAAI GVVDEEGKGL
SDFVTYGVPE PVAREIGHRP DGHRGLLGAL IHDPRPVRLA DLTADPRFAG FPPGHPPMRT
FLGVPIRVQG EIFGNLYLAG KDGGGEFTDY DLHMVRVLAT EAGIAIGNAR LYEAARQRER
WIDGSVAVTT ALLSGGDADD ALAVVAEQAR HLAASAAGIV LLPAEDGGLE IVAVSETEPT
GALGVIIPAQ SPVVGMLLGG EAVFVDDSAT DFRMITTLAG RFGPSMLLPL HSGGRVLGAL
ATPRARGGRP FTETERTLAA QFASQAALAL MMAEAQRDRE RLAVYEDRDR IARDLHDLVI
QRLFATGMML ESAQRRSDVP EVQTGVGRAV DELDVTIQEI RTAIFALQQE PAEAPSGLRT
RVLREINMAA VPLGFKPSYR FVGPVDAVVG ELTGKNLIAA LREALSNAFR HAVASRIDVV
VDATATLPDG RAAVRLTVAD DGVGIPPGGR RSGLRNLARR AESLGGASWF GPGLGEDGGG
TAVVWQAPL
//
