ID A0A1Q5MT93_9ACTN Unreviewed; 423 AA.
AC A0A1Q5MT93;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Beta-ACP synthase {ECO:0000313|EMBL:OKK17356.1};
GN ORFNames=AMK16_21120 {ECO:0000313|EMBL:OKK17356.1};
OS Streptomyces sp. CB00455.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK17356.1, ECO:0000313|Proteomes:UP000185643};
RN [1] {ECO:0000313|EMBL:OKK17356.1, ECO:0000313|Proteomes:UP000185643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK17356.1,
RC ECO:0000313|Proteomes:UP000185643};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK17356.1}.
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DR EMBL; LIVQ01000005; OKK17356.1; -; Genomic_DNA.
DR RefSeq; WP_073918212.1; NZ_LIVQ01000005.1.
DR AlphaFoldDB; A0A1Q5MT93; -.
DR STRING; 1703927.AMK16_21120; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000185643; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000185643};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 3..417
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 423 AA; 44246 MW; 995764AD0F93CEA7 CRC64;
MTPRRVAVTG VGVVAPGGIG ASAFWDLLSN GRTATRGITL FDPAGFRSRI AAEVDFDPAA
HGLDENETAR ADRYIQFALV AAREALLDAG LDLTTEEAWR TGVSLGTAVG GTTRLEHDYV
AVSQSGAWWD VDHKLAGPHL HRAFTPATLA SAVAEQTGAR GPVQTVSTGC TSGLDAVGYA
VHSIAEGRMD ICIAGASDSP ISPITVACFD AIKATSPNND DPAHASRPFD ADRDGFVLGE
GGAVLVLEEL EHARARGASV YCEIGGYATF GNAHHMTGLT AEGLEMARAI ETALDQARIS
ADDIDYVNAH GSGTKQNDRH ETAAVKRVLG DHAYKTPMTS IKSMVGHSLG AIGAIELAAC
VLAMTHQVVP PTANYETPDP ECDLDYVPRT ARGLALRNVL SVGSGFGGFQ SAVVMTRPKE
EVS
//
