ID A0A1Q5MZC2_9ACTN Unreviewed; 996 AA.
AC A0A1Q5MZC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Hyaluronidase {ECO:0000313|EMBL:OKK19564.1};
GN ORFNames=AMK16_15885 {ECO:0000313|EMBL:OKK19564.1};
OS Streptomyces sp. CB00455.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK19564.1, ECO:0000313|Proteomes:UP000185643};
RN [1] {ECO:0000313|EMBL:OKK19564.1, ECO:0000313|Proteomes:UP000185643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK19564.1,
RC ECO:0000313|Proteomes:UP000185643};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK19564.1}.
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DR EMBL; LIVQ01000003; OKK19564.1; -; Genomic_DNA.
DR RefSeq; WP_073915227.1; NZ_LIVQ01000003.1.
DR AlphaFoldDB; A0A1Q5MZC2; -.
DR STRING; 1703927.AMK16_15885; -.
DR Proteomes; UP000185643; Unassembled WGS sequence.
DR GO; GO:0016231; F:beta-N-acetylglucosaminidase activity; IEA:UniProt.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 1.20.58.460; Hyaluronidase post-catalytic domain-like; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR015882; HEX_bac_N.
DR InterPro; IPR049019; NagJ-like_helical.
DR InterPro; IPR011496; O-GlcNAcase_cat.
DR PANTHER; PTHR13170; O-GLCNACASE; 1.
DR PANTHER; PTHR13170:SF16; PROTEIN O-GLCNACASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF02838; Glyco_hydro_20b; 1.
DR Pfam; PF07555; NAGidase; 1.
DR Pfam; PF21774; NagJ_C; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF140657; Hyaluronidase post-catalytic domain-like; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000185643};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..996
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039405290"
FT DOMAIN 856..994
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 871..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 102740 MW; 173B388EDA0788AB CRC64;
MQLRGRKRAA VAAVAVIGAL WGGAVASAPP GSPGVASAPV VAGGAAGGAA PAVAAGAVLD
PGADIPRTAA EGPAVWPRPR SMAADPAREV ALGAEAALVV PAGADPYAVQ VVRDALRAAG
VRTLHERAPG APLPERGAVV RLQGPDAQEA LRALGAAGAD DLPDGGYRLA VGRTGGRATV
ALAGVGQDGL FHAAQTLRAV LAAGGAKVPG VLVRDWPATA VRGIAEAFYG QPWTREQRLA
QLDFMARTKQ NRLLLAPGDD VYRTTAWRQE YPADRQEEFR ALAERARADH VVLGWAVAPG
QSMCLSSAAD RAALTRKLDA MWELGLRAFQ VQFPDVSYTE WGCGADREKY GKGPAAAAKA
HAEVAGEVAA HLAARHPGAA PLSLLPTEFY QEGATAYRTA LAAALDARVE VAWTGVGVVP
RTITGKELAG ARAALGHPLV TMDNYPVNDW DPGRVFLGPY AGREPAVAGG SAALLANAMP
QATLSRIPLF TVADFAWNPR DYRPGESWAA AVRELAGPDP RTREAVAALA GNSAASGLKQ
EESAYLGALV ERFWKARGAG DPAAGAELRK AFTVLREAPG RLPGLSGEAG PWLQRLSRYG
AAGELAVDVL TAQARGDGAA AWRASLAWAG ARTALAEPGS AVVDGAVLEP FLAKAAAEAD
AWTGASRRAG EVTKAADSWT VRLDAARPLA AVTVMTDPLA AEVRGAAVEA HVPGEGWRKV
AAADASGWTQ VDTSGLRADA VRLSWAGTAP AVHQVVPWPA DGPQVRFELA DGAAADVEIG
GAPRRVSAEL AALGPAAVRG TVSAQPPHGI EVRLPGTVVA PRGGRVPVSF EVVAAPSTPA
GTYRVPVAFG GESRTLTVRA VARTGGPDLL RSARASSSAD EAPGFPASAA VDGSPSTRWS
SPAVDGAWWQ AQPAAPARLG RLELYWQEAY PSAYRVETSA DGVAWRPAAA VQASRGGHET
VRMDAPDTRF VRVTCEKRAT RFGCSLWSAE AYAVTP
//
