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Database: UniProt
Entry: A0A1Q5N4T9_9ACTN
LinkDB: A0A1Q5N4T9_9ACTN
Original site: A0A1Q5N4T9_9ACTN 
ID   A0A1Q5N4T9_9ACTN        Unreviewed;       400 AA.
AC   A0A1Q5N4T9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Serine protease {ECO:0000313|EMBL:OKK21450.1};
GN   ORFNames=AMK09_13325 {ECO:0000313|EMBL:OKK21450.1};
OS   Streptomyces sp. CB02488.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK21450.1, ECO:0000313|Proteomes:UP000186200};
RN   [1] {ECO:0000313|EMBL:OKK21450.1, ECO:0000313|Proteomes:UP000186200}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CB02488 {ECO:0000313|EMBL:OKK21450.1,
RC   ECO:0000313|Proteomes:UP000186200};
RX   PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA   Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA   Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA   Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT   "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL   MBio 7:e02104-e02116(2016).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKK21450.1}.
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DR   EMBL; LIVO01000004; OKK21450.1; -; Genomic_DNA.
DR   RefSeq; WP_073734946.1; NZ_LIVO01000004.1.
DR   AlphaFoldDB; A0A1Q5N4T9; -.
DR   STRING; 1703920.AMK09_13325; -.
DR   OrthoDB; 9798386at2; -.
DR   Proteomes; UP000186200; Unassembled WGS sequence.
DR   GO; GO:0110165; C:cellular anatomical entity; IEA:UniProt.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR   Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   PANTHER; PTHR43806:SF11; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000186200};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           36..400
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012569863"
FT   DOMAIN          63..118
FT                   /note="Inhibitor I9"
FT                   /evidence="ECO:0000259|Pfam:PF05922"
FT   DOMAIN          152..380
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        161
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        194
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        346
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   400 AA;  40447 MW;  085C97D8D71F280C CRC64;
     MALHKRTHRI KLTAAITAVA AAAGITLLGS PMAGAAPAPA MGKIYGADAA TAVSGSYIVM
     LDHKADKSKL AKEYGGKLKR NYSSAINGFS ASGLSQTEAK RLAADPSVSK VVQNKKFHVD
     ATQANPPSWG LDRIDQTGTA GDNAYTYPDS AGEGVTAYVI DTGVRITHEE FEGRASYGYD
     AVDDDDNADD GYGHGTHVAG TIAGATYGVA KKAKIVAVRV LDDSGSGTTE QVVAGIDWVT
     ANHEGPSVAN MSLGGGADEA LDAAVQKSIA SGVTYGVAAG NESGDASESS PARVPEAITV
     ASSTVDDEQS SFSNYGSLVD LYAPGSDITS AWNDSDTGSD TISGTSMATP HVVGAAAVYL
     AGHPDATPAD VSTALTDGAT PDAISNATAG TANKLLKVVE
//
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