ID A0A1Q5N5J1_9ACTN Unreviewed; 247 AA.
AC A0A1Q5N5J1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Phosphoesterase {ECO:0000256|RuleBase:RU362039};
DE EC=3.1.4.- {ECO:0000256|RuleBase:RU362039};
GN ORFNames=AMK09_12595 {ECO:0000313|EMBL:OKK21697.1};
OS Streptomyces sp. CB02488.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK21697.1, ECO:0000313|Proteomes:UP000186200};
RN [1] {ECO:0000313|EMBL:OKK21697.1, ECO:0000313|Proteomes:UP000186200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02488 {ECO:0000313|EMBL:OKK21697.1,
RC ECO:0000313|Proteomes:UP000186200};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|RuleBase:RU362039};
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily. YfcE
CC family. {ECO:0000256|ARBA:ARBA00008950, ECO:0000256|RuleBase:RU362039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK21697.1}.
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DR EMBL; LIVO01000004; OKK21697.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5N5J1; -.
DR STRING; 1703920.AMK09_12595; -.
DR OrthoDB; 9813918at2; -.
DR Proteomes; UP000186200; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR024654; Calcineurin-like_PHP_lpxH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR011152; Pesterase_MJ0912.
DR InterPro; IPR000979; Phosphodiesterase_MJ0936/Vps29.
DR NCBIfam; TIGR00040; yfcE; 1.
DR PANTHER; PTHR42850:SF2; BLL5683 PROTEIN; 1.
DR PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR Pfam; PF12850; Metallophos_2; 1.
DR PIRSF; PIRSF000883; Pesterase_MJ0912; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU362039};
KW Reference proteome {ECO:0000313|Proteomes:UP000186200}.
FT DOMAIN 3..186
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF12850"
SQ SEQUENCE 247 AA; 26591 MW; 649E2399998B34B9 CRC64;
MARVAVLSDI HANIPAFEAV LAEPDVAAAD LIVLCGDLTW GPQPQETYER ILALGERALC
VRGNADRYAA EIGTGARAAD TPRQSWIADR HSPEAIGFLT RVPFGVVVEV DGLGPVHFCH
GSPRSDHELV TPGTPPERFA RLSATLDARV LVTGHSHLQF DRTVAGLRSV NPGSVGLPYH
AAEPGTAYWA LLGPDVRLRT TRYDVSDAVD RAYRAADPDA ERYAGTLTNP PVPEKIVEEA
ESLVFVN
//
