ID A0A1Q5N644_9ACTN Unreviewed; 488 AA.
AC A0A1Q5N644;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=L-amino acid ligase {ECO:0000313|EMBL:OKK21831.1};
GN ORFNames=AMK16_00660 {ECO:0000313|EMBL:OKK21831.1};
OS Streptomyces sp. CB00455.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK21831.1, ECO:0000313|Proteomes:UP000185643};
RN [1] {ECO:0000313|EMBL:OKK21831.1, ECO:0000313|Proteomes:UP000185643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK21831.1,
RC ECO:0000313|Proteomes:UP000185643};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK21831.1}.
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DR EMBL; LIVQ01000001; OKK21831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5N644; -.
DR STRING; 1703927.AMK16_00660; -.
DR Proteomes; UP000185643; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR PANTHER; PTHR43585:SF2; ATP-GRASP ENZYME FSQD; 1.
DR PANTHER; PTHR43585; FUMIPYRROLE BIOSYNTHESIS PROTEIN C; 1.
DR Pfam; PF13535; ATP-grasp_4; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:OKK21831.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000185643}.
FT DOMAIN 115..335
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT REGION 464..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 51294 MW; 10ED67AC0D1E3148 CRC64;
MTPILFVYAK GGPPLEYAVP RIAAHAEVHV LALAPLPRTT ESVWMPGCAS VTTVPPGEGV
DLVDLICSHA RRVGAEAVLT LSEYAVVAVA HASLRLGLRG AGERVAGARD KRLMRRIWRD
AGVPVPGFAE VHAPEDITAA FETLRPPLLL KAAWSAGSTA HLTVWNEQQA EAAWKTGRSV
MEASSAQGYS ELLAADEGVS DFLLEEIVTG EASDWFDGDG WGDYVSVEGI VADGRYHPLC
ITGRMPTIAP FTERASLAPA ALPDALQHRI EEVSRAAVDA LGLDTCATHT EIKLGADGAM
WLIETAARFG GVMTTRQVET VFGFDMIGML VRQLLGREVA YPARMLTEGE GAAGSLVVLA
VDAEGRPWTE LPAWDFEAVD WASLVAPGSR VELVREHSLA PGSPVPRYEE AGGANSMAAL
CFLTAESGPE LLADCGRILA ALPDALTAPS VALTAAPTAL TATTATLTPA PTEPSALPTD
RSTPGSTA
//
