ID A0A1Q5N8D1_9ACTN Unreviewed; 750 AA.
AC A0A1Q5N8D1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Salicylyl-CoA 5-hydroxylase {ECO:0000313|EMBL:OKK22699.1};
GN ORFNames=AMK16_06410 {ECO:0000313|EMBL:OKK22699.1};
OS Streptomyces sp. CB00455.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703927 {ECO:0000313|EMBL:OKK22699.1, ECO:0000313|Proteomes:UP000185643};
RN [1] {ECO:0000313|EMBL:OKK22699.1, ECO:0000313|Proteomes:UP000185643}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB00455 {ECO:0000313|EMBL:OKK22699.1,
RC ECO:0000313|Proteomes:UP000185643};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK22699.1}.
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DR EMBL; LIVQ01000001; OKK22699.1; -; Genomic_DNA.
DR RefSeq; WP_073909615.1; NZ_LIVQ01000001.1.
DR AlphaFoldDB; A0A1Q5N8D1; -.
DR STRING; 1703927.AMK16_06410; -.
DR OrthoDB; 3169239at2; -.
DR Proteomes; UP000185643; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0003959; F:NADPH dehydrogenase activity; IEA:InterPro.
DR CDD; cd02932; OYE_YqiM_FMN; 1.
DR Gene3D; 3.30.9.20; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001155; OxRdtase_FMN_N.
DR InterPro; IPR044152; YqjM-like.
DR PANTHER; PTHR43303:SF3; BLR3436 PROTEIN; 1.
DR PANTHER; PTHR43303; NADPH DEHYDROGENASE C23G7.10C-RELATED; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF00724; Oxidored_FMN; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000185643}.
FT DOMAIN 7..321
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 387..722
FT /note="NADH:flavin oxidoreductase/NADH oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00724"
SQ SEQUENCE 750 AA; 80311 MW; DC69EBDD81EE6B0F CRC64;
MSAGALRVAV VGGGPGGLYA AALLARQGHG VEVWERGAPD ETFGFGVVLS DETLGGIEQA
DTVVHAALSS QFVRWDDVDI VHRGRLLTSG GHGFAALGRR RLLEILHERC AGLGVRLRFR
TGPVDAAALA GSHDLVVAAD GVHSATRQAG AAHFGPTVTS GRCRYIWLAA DFAFDAFRFE
IAETGHGVMQ LHAYPYAADA STVIVEMREE VWRRAGFDLC DETESADRCA KIFSEALRGR
PLHGNRSAWN RFHTVVNSRW SHGNVVLLGD AAHTAHFSIG SGTKLAVEDA LALAGALAGQ
DGVPRALAAY EAARRPAVAS TQRAAAASMR WFEEVAGYAG QPARQFAFNL LTRSRRVTHE
NLRLRDERFA RAVERDFGCP DEDTPPMFTP FTLRGLTLRN RVVVSPMDVY SAREGVPGDF
HLVHLGARAL GGAGLVMTEM VCVSAEGRIT PGCTGLYTRE QAAAWQRITD FVHTSAPGTA
LGVQLGHSGR KGSTRVMWEG MDEPLPDGNW PLTAASELPY LPGVSAVPRA LTEADMAKVR
SDFAAAAVRA ADCGFDLLEL HCAHGYLLSG FLSPLTNRRS DAYGGSLENR LRFPLEVFDA
VRAVWPGDRP MTVRLSATDW APGGTSPQEA VRIAAAFAAR GADAIDVSTG QVVADETPEY
GRSYQTPYAD RIRNALGIPV IAVGAISSWD DVNSLLLAGR ADLCAVGRPH LFDPHWTLHA
AADQAYEGPA APWPLPYRAG SRRPPTGRGA
//
