ID A0A1Q5NF22_9ACTN Unreviewed; 340 AA.
AC A0A1Q5NF22;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:OKK24901.1};
GN ORFNames=AMK09_01480 {ECO:0000313|EMBL:OKK24901.1};
OS Streptomyces sp. CB02488.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1703920 {ECO:0000313|EMBL:OKK24901.1, ECO:0000313|Proteomes:UP000186200};
RN [1] {ECO:0000313|EMBL:OKK24901.1, ECO:0000313|Proteomes:UP000186200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CB02488 {ECO:0000313|EMBL:OKK24901.1,
RC ECO:0000313|Proteomes:UP000186200};
RX PubMed=27999165; DOI=10.1128/mbio.02104-16;
RA Yan X., Ge H., Huang T., Hindra, Yang D., Teng Q., Crnovcic I., Li X.,
RA Rudolf J.D., Lohman J.R., Gansemans Y., Zhu X., Huang Y., Zhao L.X.,
RA Jiang Y., Van Nieuwerburgh F., Rader C., Duan Y., Shen B.;
RT "Strain Prioritization and Genome Mining for Enediyne Natural Products.";
RL MBio 7:e02104-e02116(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKK24901.1}.
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DR EMBL; LIVO01000001; OKK24901.1; -; Genomic_DNA.
DR RefSeq; WP_073732698.1; NZ_LIVO01000001.1.
DR AlphaFoldDB; A0A1Q5NF22; -.
DR STRING; 1703920.AMK09_01480; -.
DR OrthoDB; 105475at2; -.
DR Proteomes; UP000186200; Unassembled WGS sequence.
DR GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR CDD; cd01320; ADA; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01430; aden_deam; 1.
DR PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000186200}.
FT DOMAIN 9..334
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 340 AA; 36973 MW; D1A2CB8530B58D6E CRC64;
MDRDVRLLPK AHLHLHFTGS MRPTTLLELA DKYGVRLPEA LTSGEPPRLR ATDERGWFRF
QRLYDAARSC LRSPEDIQRL VREAAQEDVA DGSGWLEIQV DPTSYAPLLG GLIPAIEIIL
DAVDSASRET GLPIRVVIAA NRMKHPLDAR TLARLAVRYA DRGVVGFGLS NDERRGMARD
FDRAFAIARE GGLLAAPHGG ELSGPSSVRD CLDDLDASRV GHGVRAAEDP RLLRRLAERG
VTCEVCPASN VALGVYEKPS DVPLRTLFEA GVPMALGADD PLLFGSRLAA QYDLVRRHHA
FTDAELAELA RQSVRGSAAP ESVRAELLAG VDDWLAGPVA
//