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Database: UniProt
Entry: A0A1Q5PQU1_9ACTO
LinkDB: A0A1Q5PQU1_9ACTO
Original site: A0A1Q5PQU1_9ACTO 
ID   A0A1Q5PQU1_9ACTO        Unreviewed;       806 AA.
AC   A0A1Q5PQU1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=BM477_03300 {ECO:0000313|EMBL:OKL49944.1};
OS   Boudabousia marimammalium.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Boudabousia.
OX   NCBI_TaxID=156892 {ECO:0000313|EMBL:OKL49944.1, ECO:0000313|Proteomes:UP000186465};
RN   [1] {ECO:0000313|Proteomes:UP000186465}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15383 {ECO:0000313|Proteomes:UP000186465};
RA   Meng X.;
RT   "Actinomyces gypaetusis sp. nov. isolated from Gypaetus barbatus in Qinghai
RT   Tibet Plateau China.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKL49944.1}.
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DR   EMBL; MPDM01000003; OKL49944.1; -; Genomic_DNA.
DR   RefSeq; WP_075361268.1; NZ_MPDM01000003.1.
DR   AlphaFoldDB; A0A1Q5PQU1; -.
DR   STRING; 156892.BM477_03300; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000186465; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 2.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OKL49944.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186465};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          15..468
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          774..795
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          440..467
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   806 AA;  87020 MW;  C788424FB29914FF CRC64;
     MAKSSADSKE QILDTDVSEE MEKSFLEYAY SVIYSRALPD ARDGLKPVQR RIIYQMGQMG
     LTPNKGHVKS QRVVGDVMGK LHPHGDSAIY DALVRLAQDF SLRVPMIDGH GNFGSLDDGP
     AAARYTEARM AAPAIDMIKD LDEDVVDFVP NYDNQFMQPS VLPAGFPNLL VNGASGIAVG
     MATNIPPHNL GEVCAAAGYL LDHPDATTDE LMRYVPGPDL PTGGTIVGLD GIKEAYETGR
     GSFRTRAKTT IERVSARKWG IIVTELPYLV GPERVIDKLK DAVNSGKVKG ISAVTNLTDR
     HHGLRLVIEV KNGFNPEAVL ESLYKQTPLE DSFAINAVSL VDGQPQTLGL KEILRVYTRH
     RLEVVKRRTA YRLGKRQERL HLVEGLLAAV LDIDDVIAII RSSDDVTTAR KRLIFSFDLS
     EVQADHILSL QLRRLTKLAR IELETERDNL RKEIAELEAL LASDELRRHL VRDELQDTAQ
     RLSTPRRTVL TSQMPMPTKG APLEVPDGPC QLVLAADGSL SRFDTEEDLP TDGDRVANDA
     RRNVLSTSTR STVGLLDEQG IVHKLDVLTV PQLPLAASAP SFAGGAAAHL LIHTLDSEVS
     PVALLDLSED AAPLALGTKH GIVKRIRGEH PSSKESWSVI SMDEGDLVIG AAHATDDAEL
     IFISSDAQLL RFKASNVRPQ GLSASGMGGI SLRDDATLVA FAVIPAEDAE TAYVTTVTTE
     DGGLLGGLVS VAKVSPLGVF PAKGRNTQGV RSHRFLVGQK QLVGAWVTAH SPRAVDQGGQ
     PVSLPPATEK RDGSGVSVDA MIQAVG
//
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