ID A0A1Q5PQU1_9ACTO Unreviewed; 806 AA.
AC A0A1Q5PQU1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=BM477_03300 {ECO:0000313|EMBL:OKL49944.1};
OS Boudabousia marimammalium.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Boudabousia.
OX NCBI_TaxID=156892 {ECO:0000313|EMBL:OKL49944.1, ECO:0000313|Proteomes:UP000186465};
RN [1] {ECO:0000313|Proteomes:UP000186465}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15383 {ECO:0000313|Proteomes:UP000186465};
RA Meng X.;
RT "Actinomyces gypaetusis sp. nov. isolated from Gypaetus barbatus in Qinghai
RT Tibet Plateau China.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKL49944.1}.
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DR EMBL; MPDM01000003; OKL49944.1; -; Genomic_DNA.
DR RefSeq; WP_075361268.1; NZ_MPDM01000003.1.
DR AlphaFoldDB; A0A1Q5PQU1; -.
DR STRING; 156892.BM477_03300; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000186465; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC/MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OKL49944.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186465};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 15..468
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 774..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 440..467
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 806 AA; 87020 MW; C788424FB29914FF CRC64;
MAKSSADSKE QILDTDVSEE MEKSFLEYAY SVIYSRALPD ARDGLKPVQR RIIYQMGQMG
LTPNKGHVKS QRVVGDVMGK LHPHGDSAIY DALVRLAQDF SLRVPMIDGH GNFGSLDDGP
AAARYTEARM AAPAIDMIKD LDEDVVDFVP NYDNQFMQPS VLPAGFPNLL VNGASGIAVG
MATNIPPHNL GEVCAAAGYL LDHPDATTDE LMRYVPGPDL PTGGTIVGLD GIKEAYETGR
GSFRTRAKTT IERVSARKWG IIVTELPYLV GPERVIDKLK DAVNSGKVKG ISAVTNLTDR
HHGLRLVIEV KNGFNPEAVL ESLYKQTPLE DSFAINAVSL VDGQPQTLGL KEILRVYTRH
RLEVVKRRTA YRLGKRQERL HLVEGLLAAV LDIDDVIAII RSSDDVTTAR KRLIFSFDLS
EVQADHILSL QLRRLTKLAR IELETERDNL RKEIAELEAL LASDELRRHL VRDELQDTAQ
RLSTPRRTVL TSQMPMPTKG APLEVPDGPC QLVLAADGSL SRFDTEEDLP TDGDRVANDA
RRNVLSTSTR STVGLLDEQG IVHKLDVLTV PQLPLAASAP SFAGGAAAHL LIHTLDSEVS
PVALLDLSED AAPLALGTKH GIVKRIRGEH PSSKESWSVI SMDEGDLVIG AAHATDDAEL
IFISSDAQLL RFKASNVRPQ GLSASGMGGI SLRDDATLVA FAVIPAEDAE TAYVTTVTTE
DGGLLGGLVS VAKVSPLGVF PAKGRNTQGV RSHRFLVGQK QLVGAWVTAH SPRAVDQGGQ
PVSLPPATEK RDGSGVSVDA MIQAVG
//