ID A0A1Q5Q129_9ACTO Unreviewed; 1176 AA.
AC A0A1Q5Q129;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=BSZ39_08870 {ECO:0000313|EMBL:OKL53573.1};
OS Bowdeniella nasicola.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Bowdeniella.
OX NCBI_TaxID=208480 {ECO:0000313|EMBL:OKL53573.1, ECO:0000313|Proteomes:UP000185628};
RN [1] {ECO:0000313|Proteomes:UP000185628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19116 {ECO:0000313|Proteomes:UP000185628};
RA Meng X.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKL53573.1}.
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DR EMBL; MQVR01000053; OKL53573.1; -; Genomic_DNA.
DR RefSeq; WP_073716984.1; NZ_MQVR01000053.1.
DR AlphaFoldDB; A0A1Q5Q129; -.
DR STRING; 208480.SAMN02910418_01350; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000185628; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000185628}.
FT DOMAIN 639..800
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 818..975
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1176 AA; 128634 MW; 2A00031809AC49BB CRC64;
MDLRPLLPLL AHDASFADAV AAVPDRGLKT LVAPAGIRPA LLAAAAEARP LAIVTPTGRQ
ADELAAALRG YLPDADVAVL PAWETLPHEK LSPRPDTVAR RLAVLRRLAH PDPHTPGAGP
LRVVIIPVRS LIQPVVAGAA ELEPVRLAVG EEIDMQEVVA RLADAAYTRV DMVERRGEFA
VRGGLLDIFP PTESHPLRVE FFGDEVDEIR SFSVADQRSI EASEFLWAPP AREILLTDRV
RARAREAIAD FPGARDMLER LSEGIAVEGM ESLAGVLVED MHSVVANLDP EMLLVALDPE
RIARRVDDLL ATTEEFLSAA WTSAAAGGEA PLVLRKASFL TLDQTREAAL ERRLGWWELT
ELPSGAEGEH VLDAEAASRY RGRIDELATD LAAWLHEGRH VVITTDGPGP GRRVAEQLAD
AGIAAAYAPD APAGLPTGTV HVTLGTLAEG YLAPGARVVH LAHSDLTGRR RDTAAAGQKM
PTKRRKTVDP LALKPGDYVV HDTHGVGQFV ELITRSVGAG AKKGMREYVV IEYAASRRGG
PPDRLFVPTD SLDQVTKYTG GEAPSVNRLG GSDWAKTKSR ARKAIREIAA ELIRLYAART
SAKGHAFSPD TPWQRELEEA FPYMETPDQL ATIEDVKADM ERPVPMDRLI CGDVGYGKTE
IAVRAAFKAV QDGKQVAVLC PTTLLAQQHF ETFSERYGGF PVRVAALSRF QSAKEAREIK
DGLKAGTIDV VIGTHRLVTG EVHFKDLGLV IVDEEQRFGV EHKEALKQLR TDVDVLAMSA
TPIPRTLEMA VTGIREMSTL ATPPEERHPV LTYVGRYEEK QIAAAIRREL LRDGQVFFVH
NRVESIDRVA ARLHELVPEA RIGVGHGKMN ETQLEKVIVD FWNREYDVLV CTTIVETGLD
ISNANTLIVD RADAFGLSQL HQLRGRVGRG RDRAYAYFLY HPEKTLTETA YERLRTIAAN
TDLGAGMQVA MKDLEIRGAG NLLGGEQSGH IAGVGFDLYV RMVAEAVAAF KGEYSGSKDM
KLELPVDAHV PEDYIGHERL RLEAYSKIAA ARTREDLDAI AAELTDRYGP IPRVVERLFT
VAELRESARA IGLEEAIVQG QMLRVGPLQL KDSQQVRLKR LHPGTHIRLA TRQLLIPLPK
PKGFGNVALS DDEILGWVRD LFALLSAIVS ARRVPE
//
