ID A0A1Q5RK39_9BRAD Unreviewed; 554 AA.
AC A0A1Q5RK39;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN ORFNames=AC629_33335 {ECO:0000313|EMBL:OKO76060.1};
OS Bradyrhizobium sp. NAS80.1.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=1680159 {ECO:0000313|EMBL:OKO76060.1, ECO:0000313|Proteomes:UP000186592};
RN [1] {ECO:0000313|EMBL:OKO76060.1, ECO:0000313|Proteomes:UP000186592}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAS80.1 {ECO:0000313|EMBL:OKO76060.1,
RC ECO:0000313|Proteomes:UP000186592};
RA Granada C., Sant'Anna F.H., Passaglia L.;
RT "Genome of Bradyrhizobium sp. NAS80.1.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU365092}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKO76060.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LGHL01000180; OKO76060.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5RK39; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000186592; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU365092};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 68..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 114..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 166..184
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 196..214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 221..239
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 245..264
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 304..322
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 365..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 433..456
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 523..545
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 554 AA; 59033 MW; 7B7E42F71F2BCEAA CRC64;
MWNQIYNPLN NAALSTIAAA IPVVSLLIMI ASGRVKAHIA AIIAVIITNL ITIFIFTMPA
GMSIRASVLG IVTGFFPIGW IVLNVIFLYQ VTVATGRFEL LKRAIGGVTE DRRLQLLLVA
FSFGAFFEGA SGFGTPVAIT GAVLIGLGFS PLAASGLSLI ANTAPVAYGA LGTPILGLAS
VTGLDPYILG AMVGRQLPFF SLIVPFWVVW AFAGWRGMKD VWPAILVTGI SFAVPQFVIS
NYINPWIVDI GASLISMGAL ILFLKVWQPK QLWLSPELRG HDPSAAQMQK ATPLDKTPLS
QSELWSALLP WIIVCIVMLI WGNGAFKTWA NSIFTWNYAV PDLHQMINKM PPVAAKPTAE
GAVFAFTYLS FTGTGMLIAA IISGILMGVG PGRLLTEYGR TIRLCAISLI TISAMLAIGT
LTRLSGVDAT LGLAFAATGV LYPFFGTLLG WLGVALTGSD TASNILFGNL QKITSQQIGL
SPILMAAANS SGGVMGKMID AQSIVVASTA TRWYGHEGTI LRFVFWHSIV LACLVGVLVT
LQAYVWPFTA LVLH
//
