ID A0A1Q5TZ29_9GAMM Unreviewed; 401 AA.
AC A0A1Q5TZ29;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Multidrug resistance protein MdtH {ECO:0000256|HAMAP-Rule:MF_01529};
GN Name=mdtH {ECO:0000256|HAMAP-Rule:MF_01529};
GN ORFNames=Xentx_02408 {ECO:0000313|EMBL:OKP05490.1};
OS Xenorhabdus thuongxuanensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=1873484 {ECO:0000313|EMBL:OKP05490.1, ECO:0000313|Proteomes:UP000186277};
RN [1] {ECO:0000313|EMBL:OKP05490.1, ECO:0000313|Proteomes:UP000186277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=30TX1 {ECO:0000313|EMBL:OKP05490.1,
RC ECO:0000313|Proteomes:UP000186277};
RA Kaempfer P., Tobias N.J., Phan Ke L., Bode H.B., Glaeser S.P.;
RT "Xenorhabdus thuongxuanensis sp. nov. and Xenorhabdus eapokensis sp. nov.,
RT isolated from Steinernema species.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01529};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01529}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC MdtH (TC 2.A.1.2.21) subfamily. {ECO:0000256|HAMAP-Rule:MF_01529}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKP05490.1}.
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DR EMBL; MKGR01000017; OKP05490.1; -; Genomic_DNA.
DR RefSeq; WP_074020456.1; NZ_MKGR01000017.1.
DR AlphaFoldDB; A0A1Q5TZ29; -.
DR OrthoDB; 56516at2; -.
DR Proteomes; UP000186277; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd17329; MFS_MdtH_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR HAMAP; MF_01529; MFS_MdtH; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR022855; Multidrug-R_MdtH.
DR PANTHER; PTHR23517:SF2; MULTIDRUG RESISTANCE PROTEIN MDTH; 1.
DR PANTHER; PTHR23517; RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01529};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01529};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01529};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01529}; Transport {ECO:0000256|HAMAP-Rule:MF_01529}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 100..116
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 136..159
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 165..189
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 210..235
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 247..264
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 299..317
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT TRANSMEM 368..385
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01529"
FT DOMAIN 4..392
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 401 AA; 44582 MW; 68CBCFC9152755BD CRC64;
MSLVSQARSL GKYFLLFDNL LVVLGFFVVF PLISIRFVEQ LGWAAVIVGF ALGLRQLVQQ
GLGIFGGAIA DRFGAKPMIV TGMLLRALGF ALMAVAFEPW VLLLSCILSG LGGTLFDPPR
AALVIKLTRP HERNRFYSLL LMQDSAGAVI GALIGSWLLQ YNFNIVCWIG ATIFVLAALF
NALFLPAYRI STVRTPIKEG MRRVVKDRRF FYYVLTLAGY FVLSVQVMLM FPIVIHEISG
TATAVKWMYA IEATISLTLL YPIARWSEKY FRQEQRLIAG LFLMSLCMFP IGWVNQLHLI
FGLICLFYLG MVTAEPARET LSASLADPRA RGSYMGFSRL GLALGGALGY TGGGWLYDAG
HALNIPQLPW ILLGLVGLMT IYALHHQFNQ KKIEPIIINK H
//
