ID A0A1Q5UEV0_9EURO Unreviewed; 512 AA.
AC A0A1Q5UEV0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENSUB_3593 {ECO:0000313|EMBL:OKP10989.1};
OS Penicillium subrubescens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1316194 {ECO:0000313|EMBL:OKP10989.1, ECO:0000313|Proteomes:UP000186955};
RN [1] {ECO:0000313|EMBL:OKP10989.1, ECO:0000313|Proteomes:UP000186955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 132785 {ECO:0000313|EMBL:OKP10989.1,
RC ECO:0000313|Proteomes:UP000186955};
RA De Vries R.P., Peng M., Dilokpimol A., Hilden K., Makela M.R.,
RA Grigoriev I., Riley R., Granchi Z.;
RT "Genome sequence of the ascomycete fungus Penicillium subrubescens.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKP10989.1}.
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DR EMBL; MNBE01000309; OKP10989.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q5UEV0; -.
DR STRING; 1316194.A0A1Q5UEV0; -.
DR OrthoDB; 5477821at2759; -.
DR Proteomes; UP000186955; Unassembled WGS sequence.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0050334; F:thiaminase activity; IEA:InterPro.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR CDD; cd19367; TenA_C_ScTHI20-like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR004305; Thiaminase-2/PQQC.
DR InterPro; IPR027574; Thiaminase_II.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR NCBIfam; TIGR04306; salvage_TenA; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF03070; TENA_THI-4; 1.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000186955}.
FT DOMAIN 13..278
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
FT DOMAIN 301..507
FT /note="Thiaminase-2/PQQC"
FT /evidence="ECO:0000259|Pfam:PF03070"
SQ SEQUENCE 512 AA; 56102 MW; 7A7C81B20E78DB3E CRC64;
MSVKRVLVIA GSDSSGGAGL EADQRVLAAH GCYALTATTG LTAQNTLGVQ DIFVVPPEFV
RKQINAGLED VGADVVKLGM LSSAETIDVI AETLQAHKVP AIVLDPVMVS TSGSQLLPEK
AVEGLRFKLL PMTTVLTPNI PEAQLLIKDS GSEVPEPADI SEMIDLARRI CSLGPKAVLL
KGGHLPLTKD HKVAKSPEES TTVIDVLYDS ETSTTTLFET DYLVSKNTHG TGCSLASAIS
ANLAMGKDMV RAVRSAVRFV EAGIRTSVDL GKGSGPINHF HSIYTMPFAP GRFLEYIMDR
PDVQGAWEKF IKHDFVEGMG QGTLPVERFK EYLVQDYLYL VQFARSNALA AYKSSEMDSI
AASAQIVLHI QREMALHIDY CASFGLSKQE MEASPETIAC TAYSRYILDV GQSEDWLALQ
MALAPCLIGY GTIARRLHSD ENTLRQGNQY WKWIENYVAD DYTEAVRLGS ALLENHVQKV
SPSRLEELIR IFMRATELEI SFWDMGLSDQ KY
//
