ID A0A1Q5UFA9_9EURO Unreviewed; 1713 AA.
AC A0A1Q5UFA9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=ATP-dependent bile acid permease {ECO:0000313|EMBL:OKP11168.1};
GN ORFNames=PENSUB_3190 {ECO:0000313|EMBL:OKP11168.1};
OS Penicillium subrubescens.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1316194 {ECO:0000313|EMBL:OKP11168.1, ECO:0000313|Proteomes:UP000186955};
RN [1] {ECO:0000313|EMBL:OKP11168.1, ECO:0000313|Proteomes:UP000186955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 132785 {ECO:0000313|EMBL:OKP11168.1,
RC ECO:0000313|Proteomes:UP000186955};
RA De Vries R.P., Peng M., Dilokpimol A., Hilden K., Makela M.R.,
RA Grigoriev I., Riley R., Granchi Z.;
RT "Genome sequence of the ascomycete fungus Penicillium subrubescens.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Cyclase 1 superfamily.
CC {ECO:0000256|ARBA:ARBA00007865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKP11168.1}.
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DR EMBL; MNBE01000293; OKP11168.1; -; Genomic_DNA.
DR STRING; 1316194.A0A1Q5UFA9; -.
DR OrthoDB; 3295317at2759; -.
DR Proteomes; UP000186955; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0004061; F:arylformamidase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:InterPro.
DR CDD; cd18596; ABC_6TM_VMR1_D1_like; 1.
DR CDD; cd18604; ABC_6TM_VMR1_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.50.30.50; Putative cyclase; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR007325; KFase/CYL.
DR InterPro; IPR037175; KFase_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF368; BILE ACID TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF04199; Cyclase; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF102198; Putative cyclase; 1.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000186955};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 327..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..692
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1143..1164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1223..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1325..1343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 504..837
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 868..1092
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1189..1462
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1497..1713
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1713 AA; 192528 MW; 29FB48D721A5E870 CRC64;
MSASKNDQVI PFEALPLDPN GPRGNAWGRF GPNDELGTLN LLTPEVIVQA AKEICTGIRI
SLDWPLSMPS YPSFDRNPFK QELVLRNPNC IYDDILSFNS QGSTQWDGFR HYANQKMRRF
YNGHTTEEIE SSDVIGLHTV AEHGGMTGRG ILLDFADWAE SNSVSISALE SQAITLDSIK
QVVKDHQLEF RKGDILFIRS GFTAAYNKLD DQQRRDMPNR PTPDFIGVEA TEGMVRWLWG
HQFAAVAGDA PSFERAPIRG SHADPNFNLH EWVLAGWGTP IGEMFDLERL SQHCSVLRRW
QPKWTVPFIS EQDEYQGFPL EGVKHSLGWT LALLTFTGIG FSAELATAAV VITVKRPRSC
SVLLLVFYTL SFMVEIILAT ASYGKPEYQA ISRYIAASAA LMACFTILLM PFRKPSLPVI
DISTVGQTPS SDFRSPEDNL RLWQFLTVSW MAPLISLGHK RQLNEPDVWL LGFEFQHSRL
HEKFRRIRGS VLRRVLQANG LDVLIISVIA VVQMICTFST PVLLQQLLQA MQDPTKPKRV
PLTYAVLALV LRLVAAQSQV LNLWYGRRCY ERSRGEMVMM VYEKALSRKN ILGLHVAGEQ
KQPGGEETIE GDPTINEVEV LPTTKPGFWG RLFSVKRKPQ LKKPKEAATL GKIFNLLRGD
VYDVAQRFWE IDVLIDKPLG LVIAVVLVWT LFGPSCFLGI LAVLIAQALN AVITRFLLRR
ERLTRAATDA RLQITSQFVE AIRHLRWYGW QDHWLRQVME ARQHELNRRI ITKLCTTSIN
FINAFASGVF PVVALYAYTM LAGHELRIDI IFPALQLFTM LETRLREIPS LITALINSSI
ALGRIEDFMA EPDKEQFEPE QRPDETPFRL DSCSFAWPGK LSPVLRDINV TIPRGLTVVS
GKVGAGKTAF LQALLGELDR LRGSCRLPNQ TIGYCAQTPW LQSMSIRDNI LFSAPYEEQR
YKRTLDACAL LPDLSQFKHG DLTFIGENGV GLSGGQKARV ALARAVYSAS RVLLLDDPLS
ALDHNTAEFV VRKCLSGPLM QNRTIVLVTH RTALVRDIAD QIIEIDESRA IVHSKAALSA
STKRDGIGLL LNLNDSETET DEANEDEEAA AVPDKFFEEE HRAEWGVKAR VYWNYIRAGK
YRWWALLVLV LAIYRLMAVG QSWFLKEWGE AYSQVSLSNS HLSVWQSHSV QTSLFSMSGV
DAYFIPQNPI NQLPSPHEDV RPWLWTFFGI ICFQAAAVLV SQLLMLVIVY CAGRTLFHQV
MVRVSHASFR FFDVTPVGRL MNRLTSDISV VDGNISAQFQ TIAFYAITWI SSILVIATAT
PTFLVFSLIL TIAFVLIFLR FLPTSQSLRR LEMVSLTPLL SNFGELLHGL TTVRAFRAEE
RFQNRVISVV DKFQGMDHFY WSLQAWLMYR FESLSALSTF CLTVLALYTN TTPGLVAFVL
IAANNFVDST HALCKQYGQL QMDFVSVERI DELLHIEEEP KGTIDPPAAW PTYGSDVTFE
NVTLRYAPHL DPALKEISLQ IPGGSTTAVI GRTGSGKSTL AVSLLSVVRP ETGRILIDGI
NIADVNTQAL RTRVTFVAQD PVLFPGSVRL NLDPTEEFSD QQCADVLERL CGRHGWNLET
HIEAGGKNLS QGQRQLIALT RAVLRRSPVV ILDEATASID HETSLEIQQI IREELQLSTV
ITIAHRVEAV KDAEYFVELD QGRVLRYGSV RDL
//
