ID   A0A1Q5UGA8_9EURO        Unreviewed;       414 AA.
AC   A0A1Q5UGA8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=2-dehydropantoate 2-reductase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PENSUB_2975 {ECO:0000313|EMBL:OKP11489.1};
OS   Penicillium subrubescens.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1316194 {ECO:0000313|EMBL:OKP11489.1, ECO:0000313|Proteomes:UP000186955};
RN   [1] {ECO:0000313|EMBL:OKP11489.1, ECO:0000313|Proteomes:UP000186955}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 132785 {ECO:0000313|EMBL:OKP11489.1,
RC   ECO:0000313|Proteomes:UP000186955};
RA   De Vries R.P., Peng M., Dilokpimol A., Hilden K., Makela M.R.,
RA   Grigoriev I., Riley R., Granchi Z.;
RT   "Genome sequence of the ascomycete fungus Penicillium subrubescens.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKP11489.1}.
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DR   EMBL; MNBE01000277; OKP11489.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q5UGA8; -.
DR   STRING; 1316194.A0A1Q5UGA8; -.
DR   OrthoDB; 1354873at2759; -.
DR   Proteomes; UP000186955; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186955}.
FT   DOMAIN          24..210
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          255..382
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   414 AA;  46781 MW;  3BD7BCCA06C0E26A CRC64;
     MSTWVQDVED ISRETKTPSL TGRVHIIGLG NAGTFIAHSL ASRQTPPPIT LLMHQASFYH
     AFRRKKRSLA VNYNGLDDNR TGFDVEVLHD RVWHRIPSKE EYLEASENPD IIENEEAVPE
     EEGHIECLIV CCKAYMTEKV IRGVRHRLSP DSTILFIQNG LGIIEKLNKE IFPDEKSRPN
     YMQGVLTHGL KKQDSYKVGH VNVGSLTLSP VVTGQTPLIQ AEKDTHWAPT TKYLLRLLTL
     TPSLVATADT PAGLLQYQLE RLAVGCVLSP LGAIHDCKNR ELLYNFPVSR TMRLLLLEIS
     SVICALPELR GIPGVEDRFS PERLRRMVLN VASNRPEDTS SIRNDLHYQR NTEIDFLNGW
     IVKRGEELGM KCVLNYMIQQ LVLSRMFIIN HREASAVPID FENVILSGDK GKDD
//