ID A0A1Q5Y0U6_9BACL Unreviewed; 355 AA.
AC A0A1Q5Y0U6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN ORFNames=A3849_00435 {ECO:0000313|EMBL:OKQ00207.1};
OS Paenibacillus sp. P46E.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1349436 {ECO:0000313|EMBL:OKQ00207.1, ECO:0000313|Proteomes:UP000185715};
RN [1] {ECO:0000313|EMBL:OKQ00207.1, ECO:0000313|Proteomes:UP000185715}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P46E {ECO:0000313|EMBL:OKQ00207.1,
RC ECO:0000313|Proteomes:UP000185715};
RA Ploux O.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC {ECO:0000256|RuleBase:RU362028}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a uridine in RNA = a pseudouridine in RNA;
CC Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC Evidence={ECO:0000256|RuleBase:RU362028};
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKQ00207.1}.
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DR EMBL; LVYZ01000001; OKQ00207.1; -; Genomic_DNA.
DR RefSeq; WP_074109658.1; NZ_LVYZ01000001.1.
DR AlphaFoldDB; A0A1Q5Y0U6; -.
DR OrthoDB; 9773999at2; -.
DR Proteomes; UP000185715; Unassembled WGS sequence.
DR GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR NCBIfam; TIGR00005; rluA_subfam; 1.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF44; RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU362028}.
FT DOMAIN 93..242
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
FT ACT_SITE 140
FT /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ SEQUENCE 355 AA; 39959 MW; 1C0A45FAA8E801C3 CRC64;
MTTSYYSPIS YQVPPSEDGW LLKTILQKRM DVSRKLLSRL KMTDQGIMLN GERVYISVRV
VAGDTVEIRM EQETSEDILP QPIPFEILYE DEHLLVVNKA AGIIVHPTHG HYTDTLANGV
VYYWAQKSEQ FRFRPVHRLD QETSGVLVIA KNPYSHQHIS EQMIAGTVDK RYNAWVHGVP
AVPSGDIDGP IDRDPAEPHR RIVTPDGYPS LTRYEVKEVY PAAAKVELKL ESGRTHQIRV
HMGSIGCPLI GDGMYRHPLY AKAGVPAGVP QAQIAEELDT EEQAQLERTE ELDGAERAQL
KRIMELDASI PRQALHAVRL SFQHPVLRTD LVFEAPLPPD LAMLQERLQL DAAGK
//