GenomeNet

Database: UniProt
Entry: A0A1Q5Y0U6_9BACL
LinkDB: A0A1Q5Y0U6_9BACL
Original site: A0A1Q5Y0U6_9BACL 
ID   A0A1Q5Y0U6_9BACL        Unreviewed;       355 AA.
AC   A0A1Q5Y0U6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   ORFNames=A3849_00435 {ECO:0000313|EMBL:OKQ00207.1};
OS   Paenibacillus sp. P46E.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1349436 {ECO:0000313|EMBL:OKQ00207.1, ECO:0000313|Proteomes:UP000185715};
RN   [1] {ECO:0000313|EMBL:OKQ00207.1, ECO:0000313|Proteomes:UP000185715}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P46E {ECO:0000313|EMBL:OKQ00207.1,
RC   ECO:0000313|Proteomes:UP000185715};
RA   Ploux O.;
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OKQ00207.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LVYZ01000001; OKQ00207.1; -; Genomic_DNA.
DR   RefSeq; WP_074109658.1; NZ_LVYZ01000001.1.
DR   AlphaFoldDB; A0A1Q5Y0U6; -.
DR   OrthoDB; 9773999at2; -.
DR   Proteomes; UP000185715; Unassembled WGS sequence.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   NCBIfam; TIGR00005; rluA_subfam; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF44; RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362028}.
FT   DOMAIN          93..242
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
FT   ACT_SITE        140
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ   SEQUENCE   355 AA;  39959 MW;  1C0A45FAA8E801C3 CRC64;
     MTTSYYSPIS YQVPPSEDGW LLKTILQKRM DVSRKLLSRL KMTDQGIMLN GERVYISVRV
     VAGDTVEIRM EQETSEDILP QPIPFEILYE DEHLLVVNKA AGIIVHPTHG HYTDTLANGV
     VYYWAQKSEQ FRFRPVHRLD QETSGVLVIA KNPYSHQHIS EQMIAGTVDK RYNAWVHGVP
     AVPSGDIDGP IDRDPAEPHR RIVTPDGYPS LTRYEVKEVY PAAAKVELKL ESGRTHQIRV
     HMGSIGCPLI GDGMYRHPLY AKAGVPAGVP QAQIAEELDT EEQAQLERTE ELDGAERAQL
     KRIMELDASI PRQALHAVRL SFQHPVLRTD LVFEAPLPPD LAMLQERLQL DAAGK
//
DBGET integrated database retrieval system