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Database: UniProt
Entry: A0A1Q6CIP4_9GAMM
LinkDB: A0A1Q6CIP4_9GAMM
Original site: A0A1Q6CIP4_9GAMM 
ID   A0A1Q6CIP4_9GAMM        Unreviewed;       365 AA.
AC   A0A1Q6CIP4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 7.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=BI291_12725 {ECO:0000313|EMBL:OKY26269.1};
OS   Thalassotalea sp. PP2-459.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Thalassotalea.
OX   NCBI_TaxID=1742724 {ECO:0000313|EMBL:OKY26269.1, ECO:0000313|Proteomes:UP000186791};
RN   [1] {ECO:0000313|EMBL:OKY26269.1, ECO:0000313|Proteomes:UP000186791}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PP2-459 {ECO:0000313|EMBL:OKY26269.1,
RC   ECO:0000313|Proteomes:UP000186791};
RA   Barja J.L., Dubert J.;
RT   "Draft genome of the tyrosinase inhibitors producing Thalassotalea sp.
RT   PP2-459.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OKY26269.1}.
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DR   EMBL; MKQD01000039; OKY26269.1; -; Genomic_DNA.
DR   RefSeq; WP_074498494.1; NZ_MKQD01000039.1.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000186791; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000186791};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186791};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       49    348       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   365 AA;  40345 MW;  E060F853329252BC CRC64;
     MSELKSKVIS PQGSLNNIHV NAEEVLLTPE QLREELPLST KGREFIINAR QDISNIIHKK
     DHRFLVISGP CSIHDVEAAK EYAQQLKTLH DQYKDTLYIV MRVYFEKPRT TVGWKGLIND
     PHMNGSFDVE NGLRKARELL LYLTDLGLPL ATEALDPISP QYLAELFSWS AIGARTTESQ
     THREMASGLS MPIGFKNGTN GSLDVAINAM QSAASAHRFM GINQQGQVAL ITTSGNPDGH
     VILRGGKKPN YQADDIALCE QQLAKHHLEP GIVVDCSHGN SNKDYRRQPI VADDVVEQIV
     NGNKSIIGIM LESHLNEGNQ SANLPKTELQ YGVSVTDACI DFSTTKALLM RSVDQLATVL
     KTRIQ
//
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