ID A0A1Q6CN46_9GAMM Unreviewed; 1037 AA.
AC A0A1Q6CN46;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=BI291_07275 {ECO:0000313|EMBL:OKY27848.1};
OS Thalassotalea sp. PP2-459.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Thalassotalea.
OX NCBI_TaxID=1742724 {ECO:0000313|EMBL:OKY27848.1, ECO:0000313|Proteomes:UP000186791};
RN [1] {ECO:0000313|EMBL:OKY27848.1, ECO:0000313|Proteomes:UP000186791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PP2-459 {ECO:0000313|EMBL:OKY27848.1,
RC ECO:0000313|Proteomes:UP000186791};
RA Barja J.L., Dubert J.;
RT "Draft genome of the tyrosinase inhibitors producing Thalassotalea sp. PP2-
RT 459.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OKY27848.1}.
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DR EMBL; MKQD01000012; OKY27848.1; -; Genomic_DNA.
DR RefSeq; WP_074495667.1; NZ_MKQD01000012.1.
DR AlphaFoldDB; A0A1Q6CN46; -.
DR STRING; 1742724.BI291_07275; -.
DR OrthoDB; 9757904at2; -.
DR Proteomes; UP000186791; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000186791};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 441..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 542..564
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 874..891
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 924..949
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 970..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1001..1027
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1037 AA; 111532 MW; 4A61AA7C72D37466 CRC64;
MSRFFIDRPI FAWVLAIVVM LAGILAIKSL PIAQYPSIAP PAISIQAIYP GASARTLEDT
VTQVIEQKMK GLDGLLYMSS TSESNGAATL TLTFDADTDP DIAQVQVQNK LSLATPLLPE
EVQRQGVTVA KSARNFLMVL GFVSKDGSMN NIDIGDYVAS NVQDIISRVN GVGEVQLFGS
QYAMRIWLKP EMLHKYQLTP GDISAAIQAQ NAQVSAGQLG ALPAVSGQQL NATVTAQSRL
QTPEQFRDIF VKTNTDGSVV RLSDVATVEL GGENYGVVAR FNGNPATGLG IKLASGANAL
DTAQGVKDAL NELAPFFPEG LESVIPYDTT PFVSLSIEKV VSTLIEAVVL VFLVMYLFLQ
NFRATLIPTI AVPVVLLGTF AILQVFGYSI NTLTMFAMVL AIGLLVDDAI VVVENVERVM
TEEKLSPLEA TRKSMDEIKG ALVGIAMVLS AVFIPMAFFA GSTGVIYRQF SITLVTAMSL
SVLVALILTP ALCATMLKPS HVHNNSSLIG RFFTGFNRGF DKTNHGAQGF VSRMIKQSKR
YLLCYGLIVG GMIYIFSQLP SAFLPNEDQG ILFNQVSLPA GATTEQTLAV VEKMERHFLE
DQSEAVNSIF SVAGFSFAGS GQNAAIGFVN LKHWDERQRP DLSVGAVAGK AMGYFSTIKE
AFVFAFPPPA VVELGTANGF TLFLQDRVGL GHEKLLDARN MLLGMAAKSP ILAGVRPNGL
EDKPELQLDI DLAKAEALGV KQADINNTLS TAWGGRYVND FIDRGRVKKV YLQGVAEARM
VPEDINQWYV RNDEGKMVPF TAIARSYWTY GSPRLERYNG LSAMEIQGSA APGYSTGQAM
DEMERLVEQL PPGIAFEWTG ISYEERLSGG QAPLLYALSL LVVFLCLAAL YESWSVPAAV
MLIVPLGVFG AAVAAFTANL SNDIYLQVGL LTTIGLASKN AILIVEFAIH KMDEGMPLVE
AAINAVRLRL RPILMTSMAF ICGVLPLAIA SSAGSGAQNA LGISVIGGTL ASSILVVIFV
PMFFVLVRRV FPGKHVA
//
