ID   A0A1Q7T3K7_9BACT        Unreviewed;       946 AA.
AC   A0A1Q7T3K7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Peptidase S53 {ECO:0000313|EMBL:OLD83097.1};
GN   ORFNames=AUF67_01955 {ECO:0000313|EMBL:OLD83097.1};
OS   Acidobacteria bacterium 13_1_20CM_58_21.
OC   Bacteria; Acidobacteriota.
OX   NCBI_TaxID=1803438 {ECO:0000313|EMBL:OLD83097.1, ECO:0000313|Proteomes:UP000186215};
RN   [1] {ECO:0000313|EMBL:OLD83097.1, ECO:0000313|Proteomes:UP000186215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27843720;
RA   Butterfield C.N., Li Z., Andeer P.F., Spaulding S., Thomas B.C., Singh A.,
RA   Hettich R.L., Suttle K.B., Probst A.J., Tringe S.G., Northen T., Pan C.,
RA   Banfield J.F.;
RT   "Proteogenomic analyses indicate bacterial methylotrophy and archaeal
RT   heterotrophy are prevalent below the grass root zone.";
RL   PeerJ 4:E2687-E2687(2016).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLD83097.1}.
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DR   EMBL; MNIJ01000024; OLD83097.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q7T3K7; -.
DR   Proteomes; UP000186215; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR032109; Big_3_5.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   PANTHER; PTHR14218:SF42; PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR14218; PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2; 1.
DR   Pfam; PF16640; Big_3_5; 1.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        851..875
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        882..905
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          230..646
FT                   /note="Peptidase S53"
FT                   /evidence="ECO:0000259|PROSITE:PS51695"
SQ   SEQUENCE   946 AA;  97094 MW;  8A9BC8EF3E489B63 CRC64;
     MQTLLRTCVR RGVHFGIWFT VLTSLAISLP AQERAERVTA EIDDTERTAI QGSQPPMARP
     ENDAGRMAVG TKLEGISIVL SRTVTQEAAL QALIAAQQDP TSPSYHKWLT PEEFAARFGV
     ADTDIAKIQS WLEKHGFTVD SISRSKNRII FSGTVEQVES AFGTELHYYK VNGEAHFAPS
     RDISMPVAVS SVVQTVTNLS TFRPKPHVRF MSPQPAVSPN FSSGQSGNHF LTPKDVATIY
     DINPAYHAGY TGTGQAIAVV GQSSILLSDI EHFQTAAGFT PLKDPTLVLV PGSGTAMVRT
     GDEGESDLDL EYSSTIANGA TIYFVYVGNN ANYNVFDAIQ YAVDNKIAPV ISVSYGLCEA
     GLGQTGYSSL NLFLAQAATQ GQSVIAASGD SGSTDCYGVM GLTTAQQEAL AVDFPASSQY
     VTGMGGSEFL APDVAASNTT YWQAGSGSDV VSSALSYIPE QVWNDDSSQA GLSSGGGGVS
     VLTARPSWQT GVTGIPSGNF RLMPDISLSS SPNNAGYLYC SSDSTTRVTG SCANGFRDSN
     NTNLTVAGGT SFAAPIFAGM LAIINGKLNS TGQGVVNRTL YALAANSTTY AAAFHDITSG
     GNQCTAGTTY CSTAGTSEYP ATTGFDEASG LGSIDFFNLL TVWPGSSTVL VPSKTTLSAA
     TATPAAGAND AITITVASGS SSSTATPTGT LTIAVDGTTQ TSSLALVNGA AVYTFSSMTT
     DSHTITATYS GDSVYASSSS SLTVTVAANK AFKLAATSVT VSAGNAGTST VTVTPQSGYT
     GTVAWTISSS PSLLNGCFVL PNTTVAGTSA VAATLTLYTI ASSCTNSAVV LASSRRDILL
     GGVPIASRDE LLLFSPLHAT QASMAIAGLL IVGLLGRRSR RLATLAGICT LAVVGLAASG
     CAGGLSGAPS SSTPRAAKGT YTITIVGADT ASPSITAAIT MTLTIN
//