ID A0A1Q7TQC0_9BACT Unreviewed; 724 AA.
AC A0A1Q7TQC0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=AUG81_01920 {ECO:0000313|EMBL:OLD90696.1};
OS Verrucomicrobia bacterium 13_1_20CM_4_54_11.
OC Bacteria; Verrucomicrobiota.
OX NCBI_TaxID=1805408 {ECO:0000313|EMBL:OLD90696.1, ECO:0000313|Proteomes:UP000185599};
RN [1] {ECO:0000313|EMBL:OLD90696.1, ECO:0000313|Proteomes:UP000185599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27843720;
RA Butterfield C.N., Li Z., Andeer P.F., Spaulding S., Thomas B.C., Singh A.,
RA Hettich R.L., Suttle K.B., Probst A.J., Tringe S.G., Northen T., Pan C.,
RA Banfield J.F.;
RT "Proteogenomic analyses indicate bacterial methylotrophy and archaeal
RT heterotrophy are prevalent below the grass root zone.";
RL PeerJ 4:E2687-E2687(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLD90696.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MNIL01000019; OLD90696.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Q7TQC0; -.
DR Proteomes; UP000185599; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..242
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 354..596
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 724 AA; 78830 MW; 9E833374DD631A90 CRC64;
MQFFARLRSR KKKGGSRLLR YGWKVTLLIL LAGAGFAIFL FYGTWAQTFD MKNVGEMPER
NTVYDVDGKI YSRLAGANRL KVSLSEVSPF FIAAVLARED SRFYEHKGID WRGILRALVR
DVMSGSPKEG ASSITQQLAR NSLPLGGRTL SRKLLEAMVA LRIERQFTKQ QILELYVNRI
YFGNGCYGVE TASQAYFGKS ASKLNLPEAA LLAGLIRSPN RFSPLKNPEG SRIQRNAVLD
RMVALKKLSS ADAEAAKRAK IAPRPRRMPF VQENYAMDAV QRDLNLILTQ DQIDNGGLSI
YTTLDPSVQN AAQDALETQL TKIEHQSNFH HPVKANYHPP ENGEGDSAMP YLEGAVVVVD
NTSGGIRALV GGRDYAQSKF NRALVPANRQ VGSAFKPFVY TVAFSHGLLP GAAISDGPIR
PGEIDGAGNW SPGNSDGTYG GILPCSYGLI HSRNTMSVRV GQFAGLDTVQ KVANTLGISQ
NIPHGPAIYI GSFETDLKDL TAAYSVFPNA GVRKQAYVIE RIDDANHKPI YLAAHISTPA
LDPGAAWMTS RLMEEVLTRG TAATARSSLG FRLPAAGKTG TTNDYKDAWF LGYTSTLTCG
VWVGFDQPTT IISHGYGAAL ALPVWTQVMN KAAQHYPADP LQPKMAIQHA TVCSTSSQLA
TTGCMSAGTA YDIDLPADKV PTAACQVHGG EQWPFAQQFQ GLPQKAATFP GRFFKSFRKL
FGGR
//
