ID   A0A1Q7UPZ9_9CHLR        Unreviewed;       830 AA.
AC   A0A1Q7UPZ9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE            EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN   ORFNames=AUG82_06905 {ECO:0000313|EMBL:OLE03564.1};
OS   Ktedonobacter sp. 13_1_20CM_4_53_11.
OC   Bacteria; Chloroflexota; Ktedonobacteria; Ktedonobacterales;
OC   Ktedonobacteraceae; Ktedonobacter.
OX   NCBI_TaxID=1805225 {ECO:0000313|EMBL:OLE03564.1, ECO:0000313|Proteomes:UP000186213};
RN   [1] {ECO:0000313|EMBL:OLE03564.1, ECO:0000313|Proteomes:UP000186213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27843720;
RA   Butterfield C.N., Li Z., Andeer P.F., Spaulding S., Thomas B.C., Singh A.,
RA   Hettich R.L., Suttle K.B., Probst A.J., Tringe S.G., Northen T., Pan C.,
RA   Banfield J.F.;
RT   "Proteogenomic analyses indicate bacterial methylotrophy and archaeal
RT   heterotrophy are prevalent below the grass root zone.";
RL   PeerJ 4:E2687-E2687(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLE03564.1}.
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DR   EMBL; MNIY01000131; OLE03564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q7UPZ9; -.
DR   STRING; 1805225.AUG82_06905; -.
DR   Proteomes; UP000186213; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 4.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          19..479
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   830 AA;  91305 MW;  2984784C8DF5B3A7 CRC64;
     MARITDNSTT VETGIIREED FSVIMAQAFA TYGLSVVTDR ALPDARDGLK PVQRRILAGM
     RAARYLSTRP TVKSAEVVGL ILGNYHPHGD TSVYDAAVRM AQPFTLRYPL IEGQGNMGSE
     DGDAPAAYRY TEMRLSPLAE ALMADMESDT VPQHPSYKQD PKVLEPDYLP GRIPPIVNPS
     SGIAVGLSTN IPPHNLVEVL RACIALLDQP NMDVEQLMRY IQGPDFCQGG RIIGVDGIKD
     YFATGKGRII ARAEVRLEDT PRSRSLIVTQ IPPIGRDKVK ASIVKAINAR KLEGLLPDVR
     DESDTEKGMR IVLELRKDAD AAQALSQLFA ETDLQIALSF QMVFLFGEPM QAARQPKQVG
     MIDLLNYWNT HQMDVLTRRT QFELRKAEER LHIVEGLIVG AANADKIVKI FQQAEDRAAA
     RQVIEKTYKL TLIQSEVIAS MTLAQVTRLD ASKYAREKVE LQTRIGELQH LLSDRKAMLL
     LLKKEMQQLI KQFGDERRTT IDVEGQVHEP IKEVASLHER EPLAIAFTRA GTLKALPADT
     FVPRGKNGAA IYTPVRGDEQ LRQVVAATSQ DYVLCVSSSG RVFQIAAHRI PTGNRSAKGE
     PVRKLLGLAQ GEEIVTVLPV ENYDEDRYLV TFSRMGKVKK SPLSDYKTAD VDGLQDMKLA
     DGDAVAVALL SRGQGEYFVT TNTAQTLRFK DDALRAQGRV GQGVAAIALG PDAQVVSASY
     LDSEISTDSG NFLSLLVVTE SGLGKKVPLS QYPPKGRATA GIVTTELVDR DRVLLTMIID
     EKDHLLLTWK NEDGEQVTAI KAVELKAFTR AKKGVPLVKG HMLGVVALDK
//