ID A0A1Q8C0M6_9PSEU Unreviewed; 620 AA.
AC A0A1Q8C0M6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:OLF07904.1};
GN ORFNames=BU204_35125 {ECO:0000313|EMBL:OLF07904.1};
OS Actinophytocola xanthii.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae.
OX NCBI_TaxID=1912961 {ECO:0000313|EMBL:OLF07904.1, ECO:0000313|Proteomes:UP000185596};
RN [1] {ECO:0000313|EMBL:OLF07904.1, ECO:0000313|Proteomes:UP000185596}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=11-183 {ECO:0000313|EMBL:OLF07904.1,
RC ECO:0000313|Proteomes:UP000185596};
RA Wang W., Yuan L.;
RT "The draft genome sequence of Actinophytocola sp. 11-183.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLF07904.1}.
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DR EMBL; MSIE01000101; OLF07904.1; -; Genomic_DNA.
DR RefSeq; WP_075130129.1; NZ_MSIE01000101.1.
DR AlphaFoldDB; A0A1Q8C0M6; -.
DR STRING; 1912961.BU204_35125; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000185596; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OLF07904.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185596};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 32..129
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 217..350
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 436..563
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 620 AA; 65549 MW; 296AF2C269043675 CRC64;
MKLTTAQALV GWLVAQRTVL LDGSEAPLFP GVFAIFGHGN VLGLGTALSE RSDELPVWRG
HNEQGMALAA VGFAKATHRR QVGVATSSIG PGALNMVTAA GVAHANRLPL LLLPGDTFVN
RAPDPVLQQV ESFGDGTATV NDAFRPVSRW FDRIVRPEQL IATLPQVARV LTDPADCGPV
TLALPQDVQA ETFDFPDTLF EPVTHHPPRP RPDRTAVAAV AEALRGARRP LLVLGGGVRY
SGATTRARAF AEAHGVPITE TTAGRTLVPH DHPLYAGPLG ITGSASANEL AAEADLVLAV
GTRLQDFTTA SWSLFAPDVR LVTINTARFD AVKHGALPLV ADADEALAEL AELVAPWHVE
REWTARAGAV RARWDDYVDG LRAPSAGLPT YAQVVGVVNE VSEPGDYVMT ASGGLPGELI
GGWRAPGALE SGMDVEYGFS CMGYEIAGAW GAAMARSSGV VTTLLGDGSY LMLNSELFSA
AFAGHGFVAV VCDNDGYAVI DRLQRGNGAP AFNNMYADAR SRQPDTPRVD FASHAASLGC
AVLVADDLEG LRAAYTQARA HARGGRVAVV VIHTHPSAWT DAGAWWEVGV PEHSTYPEVD
DAREALDKAK SDQVRYLGRP
//
