ID   A0A1Q8DZ98_9GAMM        Unreviewed;      1234 AA.
AC   A0A1Q8DZ98;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=BTV99_10755 {ECO:0000313|EMBL:OLF40029.1};
OS   Psychrobacter sp. Rd 27.2.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Psychrobacter.
OX   NCBI_TaxID=1926479 {ECO:0000313|EMBL:OLF40029.1, ECO:0000313|Proteomes:UP000186500};
RN   [1] {ECO:0000313|EMBL:OLF40029.1, ECO:0000313|Proteomes:UP000186500}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rd 27.2 {ECO:0000313|EMBL:OLF40029.1,
RC   ECO:0000313|Proteomes:UP000186500};
RA   Romalde J.L., Lasa A.;
RT   "Genome sequence of three Psychrobacter strains.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLF40029.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MRYB01000013; OLF40029.1; -; Genomic_DNA.
DR   RefSeq; WP_075102359.1; NZ_MRYB01000013.1.
DR   AlphaFoldDB; A0A1Q8DZ98; -.
DR   STRING; 1926479.BTV99_10755; -.
DR   Proteomes; UP000186500; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07433; PHP_PolIIIA_DnaE1; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR049821; PolIIIA_DnaE1_PHP.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF160975; AF1531-like; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..71
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1234 AA;  137949 MW;  8C24EC3531858F62 CRC64;
     MAFVHLGIHS EYSITDSIVR IKPLIKAAAA DNQRALALTD LSNLYATVKF YRTCLGAGIK
     PIIGSEVIMD DEDTRLTLLA MDNEGYQNIT RIVSLGFTEG RADPDNHGTP VIKRRHILEH
     AAGVIVLFGE KSDVGHALVS SMPENADVLI TEWQAHFSDR LYFAIKRTNR SGEDAFIKAA
     IHAGAKHQLP IIAHNDVRFL EQEDFDAHEA RVCIAGSYVL ADPNRPRLYS DEQYLKTQDQ
     MAQLFADIPQ VVDNTIRLAT RCNVTLTLGI NVLPDFPVPE GETIESFFRA ESQRGLDHRL
     DKLFPVEERD ESWSDFRQQY DERLEYELDI ILSMGFPGYF LIVMDFIRWA KANGVPVGPG
     RGSGAGSLVA YALNITDLDP IHYDLLFERF LNPERVSMPD FDIDFCIEGR DRVIDYVAQT
     YGREAVSQII TFGTMAAKAV VRDVARVQSK SYFLANKISK LIPKTPGITL SQALEQEPQL
     KDLISNPDNM DYEDAIEIWE MAVKLEGVCR NVGKHAGGVL IAPHKITDFS AIYCDDEGHR
     VSQFDKDDVE DVGLVKFDFL GLRNLTVINA AVENINQRRA REGKDALVLE DLPLDDKKTY
     KLLQEAKTTA VFQLESMGMK KYLAKLQPTN IEDVIAMCAL YRPGPLDAGM VEMYIDRKHG
     REEVIYDHPN LEPILQNTNG VIVYQEQVMQ ISQVMAGYSL GGADMLRRAM GKKKPEEMAK
     QRDIFVTGAT AQGIDEATSG GVFDLMEKFA GYGFNRSHSA AYGVLAYQTA YLKQYYPAEF
     MAAVLTSDMN NTDNVVFFIN DCRENFGLTV DNPSVNRSEW HFVADTPTNI IYGLGAIKGV
     GEGAVESIVD ARRRGGPFKD LYDFCRRVDI KKVNKRTLEA LVSAGCFDDF AATLRPDLPS
     DAAYEIRGAL MSQLPSAVQA AEQDRQNNEL GMMDLFGEMD GVVAAPPLKM TPELIWGDKH
     RLKAEKNTLG LYLTGHPINE YLDELKHYTS GARLDKLTDT GYNGSCYFAG LIIDIANFGN
     RNVITLDDGT SRLEVSCYAE RFNRVKDQLK VDEVVIIKGS IRERDGRLFA RLDNAMSMVD
     ARLRWLKKIS IKIHGSDTRL LSRLQPILKS AQADIIPAPS LTQQDEPDDA TFNGNYDPAM
     GGSLYDEDGN DLLALEHDMQ QDALQNGSPY SNNALSNTDA SIHDNCLPLG LSIYETYGIA
     NVGLSEHWRI YPNDDNLQQL KSMVNEDNLH FHYS
//