ID A0A1Q8J2F9_9BURK Unreviewed; 396 AA.
AC A0A1Q8J2F9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Heme biosynthesis protein HemY {ECO:0000313|EMBL:OLL33127.1};
GN ORFNames=BTH42_04090 {ECO:0000313|EMBL:OLL33127.1};
OS Burkholderia sp. SRS-W-2-2016.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=1926878 {ECO:0000313|EMBL:OLL33127.1, ECO:0000313|Proteomes:UP000186182};
RN [1] {ECO:0000313|Proteomes:UP000186182}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SRS-W-2-2016 {ECO:0000313|Proteomes:UP000186182};
RA Chauhan A.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLL33127.1}.
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DR EMBL; MSDV01000012; OLL33127.1; -; Genomic_DNA.
DR RefSeq; WP_075296019.1; NZ_MSDV01000012.1.
DR AlphaFoldDB; A0A1Q8J2F9; -.
DR STRING; 1926878.BTH42_04090; -.
DR OrthoDB; 7053339at2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000186182; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR Pfam; PF13424; TPR_12; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000186182};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..133
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
SQ SEQUENCE 396 AA; 44509 MW; EAB4F0A535295BDA CRC64;
MAIRGLLWLA ALFAIAVLLA VGGRFDAGQI MLIYPPYRVD MSLNLFVVGL VVLFIVLYAL
LRIIRNIWRM PQRVAAYRAR QRVAKAHAAL RDAIGNLYAG RFSRAEKAAK NALANGDNKG
AAGLIAATAA HRMHEYGRRD EWLSQIDDAD WQDARLMATA DMRADGRDAD GALTALTEMQ
SQGARRIHAQ QITLRAQQQL KNWSEVLKLV KMLEKREAIH PAVAVRLRQQ AAENLLRDRR
HNADALLELW SSLSASERHS PRLADVAAEL LVALNRPQDA RKIVEEALAQ NWDARLLRRY
PDTAAGDALP LIQKAEAWQK DRPEDADLMF ALGRLCLHQQ LWGKAQSFLE RALKLADNET
LKIRSHRALA RLHEQLGDTD KASQHYRESA LSMNVT
//
