ID A0A1Q8RK30_9STRE Unreviewed; 271 AA.
AC A0A1Q8RK30;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN ORFNames=BMI76_01015 {ECO:0000313|EMBL:OLN84690.1};
OS Streptococcus sp. 'caviae'.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1915004 {ECO:0000313|EMBL:OLN84690.1, ECO:0000313|Proteomes:UP000186915};
RN [1] {ECO:0000313|EMBL:OLN84690.1, ECO:0000313|Proteomes:UP000186915}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cavy grass 6 {ECO:0000313|EMBL:OLN84690.1,
RC ECO:0000313|Proteomes:UP000186915};
RA Palakawong Na Ayudthaya S., Marshall I.P., Schreiber L., Plugge C.M.;
RT "Draft Genome Sequence of Streptococcus caviae Strain Cavy grass 6,
RT Isolated from Domesticated Guinea Pig Faecal Samples.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01811}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLN84690.1}.
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DR EMBL; MOWR01000001; OLN84690.1; -; Genomic_DNA.
DR RefSeq; WP_075345786.1; NZ_MOWR01000001.1.
DR AlphaFoldDB; A0A1Q8RK30; -.
DR STRING; 1915004.BMI76_01015; -.
DR OrthoDB; 9780552at2; -.
DR Proteomes; UP000186915; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
KW Chaperone {ECO:0000256|HAMAP-Rule:MF_01811};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01811};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01811}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..271
FT /note="Membrane protein insertase YidC"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039123228"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 196..223
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT DOMAIN 55..236
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 271 AA; 31213 MW; 66A44A4483E955AF CRC64;
MKKKYKVMGL ASVALLFLSA CGRSQVSHQS EGAWEKFVYF FAEIIRFFSV NGRIGIGIII
FTILIRTVLL PLFNMQLKSG QKMQEIQPEL KALQAKYPGK DRESRMLLAE ESQKLYKEYG
VNPYASLFPL LIQMPVLWAL YQALTRVEFL KTGSFLWMDI GDKDPYFILP VLAAAFTFLS
SWLTNKAAKE RSGVMVAMNI ILPIFILLVG FNLASGVALY WVISNAYQVF QILLLNNPFK
IIAERERLER EARELEVRKR RAKKKAQKKR R
//
