ID A0A1Q8RMZ3_9PEZI Unreviewed; 2337 AA.
AC A0A1Q8RMZ3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Lovastatin diketide synthase LovF 13 {ECO:0000313|EMBL:OLN85715.1};
GN ORFNames=CCHL11_07767 {ECO:0000313|EMBL:OLN85715.1};
OS Colletotrichum chlorophyti.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum.
OX NCBI_TaxID=708187 {ECO:0000313|EMBL:OLN85715.1, ECO:0000313|Proteomes:UP000186583};
RN [1] {ECO:0000313|EMBL:OLN85715.1, ECO:0000313|Proteomes:UP000186583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NTL11 {ECO:0000313|EMBL:OLN85715.1,
RC ECO:0000313|Proteomes:UP000186583};
RA Gan P., Narusaka M., Tsushima A., Narusaka Y., Takano Y., Shirasu K.;
RT "Draft Genome Assembly of Colletotrichum chlorophyti a pathogen of
RT herbaceous plants.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLN85715.1}.
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DR EMBL; MPGH01000155; OLN85715.1; -; Genomic_DNA.
DR STRING; 708187.A0A1Q8RMZ3; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000186583; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF53; ATROCHRYSONE CARBOXYLIC ACID SYNTHASE-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000186583}.
FT DOMAIN 1..426
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 443..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2337 AA; 255280 MW; 8D5302794B3BA48B CRC64;
MEDIAIVGMA CRFPGKATSP EKLWQMMVDK ESAWSEFPED RLNIDGYYHP SGDRQGSISF
RGAHFIRDDV AAFDASFFSV MAEDAKAIDP QQRFLLEVSY EALENAGLRV EDLKGSSTAV
YVGSFVKDYE QICLRDMDWQ PQYAATGTGN AIMSNRVSYT YDFKGPSMTI DTGCSGSLVA
VHLAAQALRA GDCSLALAAG AGLILTPNTM MPMTALNFLS PDGKCFAFDS RANGYGRGEG
IGFVVLKKLS DAVRDNDTIR AVIRGTHVNQ DGSTPGITLP SKEAQVANIR SLYSKHNLDM
QQTAFVECHG TGTQAGDFRE LKAISETLSE GRQTNNPVYV GSVKTNIGHL EGAAGVAGLI
KGVLVTEKGQ IPPNINFETG NPNIDFENWK VKVPKDLTQW PLDGTRRISV NCFGFGGTNA
HAVLDEPSSY LSERGILAHH NSKLDDARHG QSTGTSKPGE QFSKPQLFAF SSNERKGVSR
LMNTHLEHIT GLEEFNQTDA DNYAYTLACR RSVMEWKGFV VANSKADLAA KLNAKDEASF
ARSSRESKPK IAFVFCGQGA QWPQMGLELM CFKAFRNSLV AAANYLKTIG SDFDLLNEIM
KCKPASRVQD PRISQPATTA VQVALVDLLR SCNITPSSVV GHSSGEIAAA YAATSITRES
AWAISYHRGR TTSGLKRIAP LLKGAMCAVR MSYSEAMQYL ARQEEHRDLA IACINSPNSV
TISGQHDDVL WMRDDLKSSR VLCKVLDVDI AYHSEHMKLV QEDYKQSIGS IRPESASKDI
KFFSSVRGDV LPHDVIDPTY WAANLASPVQ FVQAVKSMMK SANRPDIFVE LSPHATLQSP
LAEIIAEYNR GFAPKYVSLI RRNSDTVVTT LQAIGDIWVR GYPANLLKAI SRGTDEKAYK
TLANLPSYPW NHSKTFWHES HTCTEHRFRN FGRQDLIGAP SPDATTFEPR WRGFFRISEN
PWVQDHRVQK TIVYPAAGMV VMALEAASQL SVATEEVLGF HLTDMRIERA MIIPSTAFGL
EYSLNLKQLH SKSEEDPIWE FAIYSKDEDG PWIRHADGRI SIRRKGDASP VPMSGYRDKY
LEIQSLSGDA LPPRQLYELL DVVGLNYGPC FQNVVSVATH RNSCVSKVRI PDTKSKMPAN
FEYPHIIHPA TLDSMFQTLF AIESKPMVPS QIDSVFISAS MPQGKGQEFI GFATAERRGI
CDATGSIVMV SDTEKWDMPS LVVDGLHFTA LSTPSIEDGG FIPNHRNLCS EIVWKEDYPA
CTAEDLPQII SLMAHKCPSI AVLQCGGDEK MAREILKTLS EDGSLRLSRY TMTGQQTMTA
VSQAFEKSPV ANLLEQRDWN ACEGFHARYN LIIADRESGI NIQSANELLL PEGVFLAEVA
STDVSESVYF SKEAEDSPEK LAPVTVRTGA GRRRQMLDQQ FEAHILIADI ESASLPEVLI
ILPDTIDKGM VDFVQCLGNI MSIKGFRLST GTLHDSDPKD KACISLLEVS DNFVYNWTEQ
RFRDFHKLQK TAKSLLWITR AANRRPTDPR NAPIIALART IMSEDPQKVI VTLDLDEHTS
IASETLPKIV QYVLESVISG SGETEFAEEG GKVYIPRLMP LKDLNRMIES ESQVDIVRQP
IFNHTSDTKP YQMVVSKSGI TEDSFHFVES KYEADLDPYE VEIKTLSAAL HPADLQTVLG
RTSENKLGLD VMGVITKVGS LVSGFRCGDR VLAIVPGAFK TVHRVNSFFV KHAQPLTTLF
NHAPSALLAA HYAIFTVGRP ENNKKVLIHA GASAYGQAAI HAAIHSQQEL FVTVMGQFSE
EQREILHSSY QIPDDHILDA NGDSFVAVLQ TIGKVDLVYN PTQEHVATNF KCVKASGCVV
QLADKTGRAI NVPVTSSMFV KLDIGLLQQE EPGHFADILN QVEGFVSGFV AETKQMECHS
VHQFYMSDFG SALKQVENNP NFGLTIMTAN EETCVSVAKE IRTKPLAAAI DDGTYVLAGG
LGGLGKSIAK LLADNGAKRI VFLSRSGGNA EGKSFLESLK AQGVDVEAKS VDITSLEALR
TLLPDLGKVS GVVQCAAVLK DSLFENMTHE DWTTAFGPKA IGAANLAEVF GSGTADAWFL
FLSSASGIIG NRGQANYAAA NAVQDALARS GRLTRAVSLD LGPVLEAGML VEDEETLDKL
RGAGFYGIRH RDFLTMVTRA ITGEIVTGVP TPAQIISGVG TGGLIRQNNP GDPFWSRTAL
YSFMNTVDMP VIAPGGEDTA GGGAGEADVK RMLAACSDME AAAGIVCAGL VQLMAKTMIL
LPEEIDPERT PSAYGVDSLV AVGIFRNAQG VDVSVFEILG ETSIRGLAGI VAGRGKW
//
