ID A0A1Q8TFK0_9GAMM Unreviewed; 480 AA.
AC A0A1Q8TFK0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Na+/H+ antiporter NhaC {ECO:0000313|EMBL:OLO12469.1};
GN ORFNames=BTW10_03095 {ECO:0000313|EMBL:OLO12469.1};
OS Chromohalobacter japonicus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Chromohalobacter.
OX NCBI_TaxID=223900 {ECO:0000313|EMBL:OLO12469.1, ECO:0000313|Proteomes:UP000186806};
RN [1] {ECO:0000313|EMBL:OLO12469.1, ECO:0000313|Proteomes:UP000186806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SMB17 {ECO:0000313|EMBL:OLO12469.1,
RC ECO:0000313|Proteomes:UP000186806};
RA Mavrodi D.V., Olsson B.E., Korsakova E.S., Pyankova A., Mavrodi O.V.,
RA Plotnikova E.G.;
RT "Draft genome sequences of strains Salinicola socius SMB35, Salinicola sp.
RT MH3R3-1 and Chromohalobacter sp. SMB17 from the Verkhnekamsk potash mining
RT region of Russia.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLO12469.1}.
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DR EMBL; MSDQ01000006; OLO12469.1; -; Genomic_DNA.
DR RefSeq; WP_075368112.1; NZ_MSDQ01000006.1.
DR AlphaFoldDB; A0A1Q8TFK0; -.
DR Proteomes; UP000186806; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 77..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..455
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 480 AA; 50844 MW; 2A2E371D3EEB1618 CRC64;
MSSPQGPTRL PGMMEVLAVM VGFIAIMFLS INVLGLPIQL ALFASWFLVM ALGLKLKMAY
ADMQRGLIDG IHNGMEAVLV LTTVGALIGT WIAGGIVPSI IYYGLTVMNP QIFLFAAFVI
CALTSLSTGT SFGTAGTAGV AMMGIGHSFG IPLPLVAGAV ISGAYVGDKM SPLSDTTVMT
ASLCKVNLID HIRSMMTVSA LAIPIASILF LIVGFFYVSG DVDTSRATVA MQALEANFTI
SPWLLLPAAI VIGLLTRRYP AIPVITFGAV LGSICAWWAQ GVGPIDAIRI AYVGNAMQSD
VEFLNTLLNR GGIESMLGVV ALILFALGLG GLMSQVGILK AISNGFLRWA NNPGRLTVST
MLGGFFGNFF GGAAYVSLIT ASTITEKNYD DQGVDRRVLS RNAEAGGTIT TPMVPWTDGG
VFMATTLGVS TMAYLPFLWY HMLVIAITIL YGYANIAIWR TQPKSEVQDN ANARQNFQAS
//
