ID A0A1Q9C612_SYMMI Unreviewed; 2994 AA.
AC A0A1Q9C612;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE SubName: Full=Carnosine synthase 1 {ECO:0000313|EMBL:OLP78335.1};
GN Name=CARNS1 {ECO:0000313|EMBL:OLP78335.1};
GN ORFNames=AK812_SmicGene41502 {ECO:0000313|EMBL:OLP78335.1};
OS Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS microadriatica).
OC Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC Symbiodinium.
OX NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP78335.1, ECO:0000313|Proteomes:UP000186817};
RN [1] {ECO:0000313|EMBL:OLP78335.1, ECO:0000313|Proteomes:UP000186817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP78335.1,
RC ECO:0000313|Proteomes:UP000186817};
RA Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT adaptations to a symbiotic lifestyle.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OLP78335.1}.
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DR EMBL; LSRX01001625; OLP78335.1; -; Genomic_DNA.
DR OrthoDB; 2149754at2759; -.
DR Proteomes; UP000186817; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0047730; F:carnosine synthase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0035499; P:carnosine biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.11980; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 3.40.10.10; DNA Methylphosphotriester Repair Domain; 1.
DR InterPro; IPR035451; Ada-like_dom_sf.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR031046; CARNS1.
DR PANTHER; PTHR48066; CARNOSINE SYNTHASE 1; 1.
DR PANTHER; PTHR48066:SF1; CARNOSINE SYNTHASE 1; 1.
DR Pfam; PF13535; ATP-grasp_4; 1.
DR SUPFAM; SSF57884; Ada DNA repair protein, N-terminal domain (N-Ada 10); 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000186817}.
FT DOMAIN 2691..2895
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1092..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1438..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2024..2122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2409..2485
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..778
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1319..1344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2060..2074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2075..2105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2106..2121
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2994 AA; 339846 MW; C3F77F61895002ED CRC64;
MENGPERDER MEEVPAPEAE RNSEEPTTGL VPSAGTLELQ QGGEAEAPTG RRHTEVLELP
KVDRGSAPAT PAIRPGESST PATGTKSRAE RKQEKKTARK EEKRNKRAEK SARKAEKAEE
EKPEGTSPKT PVRRKLDAAM ESAGSIESVL LLEREYKALQ RDPSHRPNFY FLIDRLISNL
RHIPRTVSAG EEERIKLTKL REEEEEAEDA EAAKRAAARV EEADEGSASR KRKLEELEEK
KRALEEENDR KRKELEEESR RLRAVEEAER RAREQRSRNP KVQVPVASEK EKGETWFERK
ATELVENYIQ SYGPQQKKSK EAAAEYTTAC KNSEQAQEDF ISALRKTQEK AEVLQKCLGR
ALEAAMAFGR EEERAQQYAQ AKDKCSRPEV PRVKARPQIP AGLQERIRKE RAQKEESSKP
GKKEGSEVPT TTKPGPFWGV RARKQPAEEE PGKEWREKIS EDVWKVGRLL KEDEKYLECT
YYPFSPEWQE KLREELLNLA HRGFAKKEDG ELYPTRRFGW QLQSTREFES INQSLERDYG
VRLVWKSQEV KGKSKSVDDF HCYPIGRGKM EKVTKFGVQY TVLGTLPPNK SMCSICWSEG
HWKSGCQLKD MVFELWEPAL AVLVPAERLR KYPCRNIVCE RYQHDKDNDF QYFYPAIAFA
DYGAVSSQIS EINSKRYKDA KLRSPEEYPE IEPPEDEREE CPALSTEQAM EYAASKKAAK
PSDPEQRMAS HSETLLDMQD QAKKRRAKLL EKESKQKAID VDDESTSKKE ESASKKARGK
GQGSESGIWT KEPLPAGHWQ DRPRRESLPS ESQEAKDALR QKLEAHKKEQ LEKEQLEEQQ
KKKLRETFET HFKKETSSKE EEPAARKGPG PDEAGSDPSS EESSESSNST DDPEGATCSE
LYLYAKESES YAQYPMETKS ETEAMEAAGS PGSIGADMPP AKDGKESTKA KEKERKDLAK
RLEPLVLCKQ AKDSGLAEVE EKAKEEEKDE EKEKERKVAK VRKVKVKAKA KAAKERKEKE
SVWEEQHAVS AIKKDIGEMS APTDIQYETL KQKNMYQEFP EVFPLASEEE GEEGDDIPIL
YTRMVRETEH KEEKKVEESL EDLEPITNPF YGKLPSPGFT DSEGEGEEVE DSGLCKGCGT
RLELTCTRPP RSVSSQYPSM PELYPGEDRY LRLQRKLRSE GKPYDKQALE DSARREHEWI
EFHLDLEREK KKESEADQVR MVRTDEFYDV AEWFVMDDTD GDDDWYVIGE TNTPDVVRAV
QTEEAPVGRA AHLDKVPDEF TELLDSTPNG KWTIMDEPER GVPEELRTPV VPVKVAPGKE
KVRVEAQPGE PTEQDHEKKN PEAGKDSVGV PYPIVQLDFM FLQGKQTERK TVEKVLKWVH
SIGHLDEVGF VGDSEEAMDQ YEGLVPDGER QGKFKNLKQI RWNERTGEDI EYEDLVEEEM
EDAPKNDQGE SPPEVSPEEL DSMDQEAAVE ELNRLSKIGV IEEFAESGAS GSEKRMDLRE
VYDWRYRDGK WRRRCRIVAR EYRAGATSTA ETFSPTASNA AARLVLILHL LNPTWVILVL
DIKDAYLQVP QQEEVLVTIS DWMKKACNIG EGIVWRLKRC LPGENVRLKH VDVRLCQLQD
WVRENTISIG TVKTVLNVAD LNTKKLTYAR RAFLMYFLSQ VEYSEGEEII HTGVDEYERY
EQEKKLKEYV SSGQVKDLIR LIQVFSVIKP VTAAVWTNDE DLDSQYSGST DAMEEVKYSR
SEVMMLMTLL VLVIPYIWMA VRKVYSEWTR ISMIGMVRIN SSSKNYIFHR TTCRYVQGKA
RNGYFIHLEY DTTVAQGYRP CYVCFPEAKK AQKHDEDDEW ELTSESTDTT ENEGCGKKCT
WCKVRKCTRK KPAHVYCSCT ECIQKYTEDL WRGQYDQVPE ASSSTQGPIG KKGSGTLEYM
PPHVNKKGNR PAGQGSKGGR RGRAAMEPVA EEQNGPMLPE GFTQETPEVE EQPPTYEDSY
DMIVDPGTPD STEERTMGPP DLCPQRPIYF AVQHKYLEVA SNRNKAATSK KRKGHEVIPD
PPSFRNPKQA ACARTAKAAK TSHPEVEKTH FQRSGTHATR PWANSQQARH QRQGVQVAHQ
EASQAKKGKN GTRHDWGPES KHAGSEQLLD CFGRAWNMNK VVVNFLNIGH YYGSKVMKLE
QQMFQWEGVR RCVRYLKTEM NLQVTGVIPE NYRGMDNGRK QLPLPADIKN MCETVEETPR
FGDQRNHRSA DDEMTIKCAY RRACRFLDND NYKEWVVQLQ DAKARTWLQK HKDMAHMRFY
FDIGTGTFDI LGGNYPTTSL AQNDVVDKHD LCNMGRFMSC ISWQPQHFLN PPQGEIEDIC
VRSKDPVAGW QLDAGALDFI ESEGGAFDGR SGIGFGEADF PLERGAAQAP PDRPDRSDRD
LSRRFEKVLS ADREICQQID EEMAGLEQEL ARIEDATLKV EQQCMQDSKA KDYMVEEAQQ
LEHKVAEAQR RLVELRDDGR ALNLESLSLR KDRNHLVEEL GFLQRSLDDE MHTLQSLQQM
NASFQAFHAD MEANTELLLH QRKELIGQVS KERELSRHDA RQNNELRNLL ERRRHAERCL
NGHIEDDEMQ CGGSGSLTGT RANEDAQLVL VKRGGSGSLT GTRANEDAQL VLVKRGCGQF
LRISSPSFAE ISAREEQQAH SLLLQLPDAV VLASEIIHEL WMGQAVLDVL SQFLEPGGFA
IILNAASYHR FGAEEFQLLA KEQNVPDKTS TLRGGFSSKR FQVSSEAVGD VDTEDDGQQG
AAVGASAVIG ARFVLESYLD GEEVDVDVVM SDGEWQYAAV SDNGPTLEPY FNETWAVSPS
LLPREKQLAL RELAVSSVKA LGFQDGIFHV ELKYTSQHGA QLIEVNARMG GGPVYSTNLK
TWGVDLVEET LFCAAGIPSR PVATRKPVEC IANADVNALR SGRLVDLSFM KPLLQREGVV
SHNCHVREGE EVVGPQDGLP TWLVEVVVSR PTPREALDFL MKLEAEIQAL VKLA
//
