ID   A0A1Q9CF42_SYMMI        Unreviewed;      1169 AA.
AC   A0A1Q9CF42;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000313|EMBL:OLP81559.1};
GN   Name=nae1 {ECO:0000313|EMBL:OLP81559.1};
GN   ORFNames=AK812_SmicGene37887 {ECO:0000313|EMBL:OLP81559.1};
OS   Symbiodinium microadriaticum (Dinoflagellate) (Zooxanthella
OS   microadriatica).
OC   Eukaryota; Sar; Alveolata; Dinophyceae; Suessiales; Symbiodiniaceae;
OC   Symbiodinium.
OX   NCBI_TaxID=2951 {ECO:0000313|EMBL:OLP81559.1, ECO:0000313|Proteomes:UP000186817};
RN   [1] {ECO:0000313|EMBL:OLP81559.1, ECO:0000313|Proteomes:UP000186817}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP2467 {ECO:0000313|EMBL:OLP81559.1,
RC   ECO:0000313|Proteomes:UP000186817};
RA   Aranda M., Li Y., Liew Y.J., Baumgarten S., Simakov O., Wilson M., Piel J.,
RA   Ashoor H., Bougouffa S., Bajic V.B., Ryu T., Ravasi T., Bayer T.,
RA   Micklem G., Kim H., Bhak J., Lajeunesse T.C., Voolstra C.R.;
RT   "Genome analysis of coral dinoflagellate symbionts highlights evolutionary
RT   adaptations to a symbiotic lifestyle.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OLP81559.1}.
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DR   EMBL; LSRX01001270; OLP81559.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Q9CF42; -.
DR   OrthoDB; 5488891at2759; -.
DR   Proteomes; UP000186817; Unassembled WGS sequence.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186817}.
FT   DOMAIN          849..1042
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
FT   REGION          421..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        574..591
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..615
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1169 AA;  127589 MW;  899432820AE5DAF7 CRC64;
     MAVLHLALAV GVGVMIFVMI WAVHRQIFAG TANATSGWIP ATVVEDYDPK QNGEAGVLVK
     LHGFFEDAYR EEKPVSGMMW KVQPNLISLR SSPPVKIQLS LLVVRWKEYF TRTTTSRSHN
     ILNEGLIRDV LAGEASCKEV FGKSGAYEVI SVFASTGRHL DAVPRELLAS SLRGSRKAAL
     FFLWPTLKKG VVEQGHVDAA AMKSLMTGME GLGVKTCWPH PWSLYEDLVS KQWAPRDCSR
     LELRIPPTTS VSCKSLREAG VEAVASSAIA ELQRLSRERG RTPLSQEQYR GVAKLTYSWM
     GVAVLPFVGE ESLQRALEKL LDGMPDIAQS VLKEFAANSE WDASFALASH KTLTKEELVM
     QKFSGNRKTV DQIEEEVRRT ASTWLERFKL EGCAPHVIRM DFLVSAPADL ADIDENIEAE
     VAGDAPGRDG FQPATSSRSP PASSPKSGGS RRMSQDEQTS MHAAADEALM RAIAQASAGL
     SMDASCTEEN ESVQEGLPSV SVSKLPSAVT VAGVPVATTG DLVYLGGGLY AAAAPAEKPA
     KKQSAAPARP RPRKPPSAIR SASAHIVGNG ARADGDSSPQ SRAQSEGQIG VGNLNPDGRG
     SSRHGSVSGS TSVGSAPGAR IWRPSGVQKL PAAKLEPPSG FGGRASRLTA EDIGKMPGDH
     SEDRASNRRL HGKEGVLLFG PNGVLAHMRD PEHRHQAMLP PSGPPQGIER RLEERKAAKQ
     ARINEILEEK ALREATEAAI SMQKRQNLAA MARNASTPEM SEDLDRKRTR LACKMDILDF
     FRGYRKAVHK LTADQQKVLQ ANLHGSALTQ LWCAWMQDSV LEKSLFFQTA SENARAEPTW
     GAMATTDKYD RQLRLWGAHG QRALMDAKVC MLGSSAIATE SLKNLVLPGI GQFTIVDNAK
     VEAADLGHNF FLEEADLGKL RSEAACKWLL EMNPDVQGAH VDQDPAKAVA QGKDFFRHFS
     LVIASQVTEL VAAQLGRLCE ELQIPLVLIT SLGFVGKIRL FVTEHCVCET KPDSEFGDLR
     LTDPFPELRR FADSIDFASL NDTEHAHVPY VVILIRALDS WRKRSEGRTL PKTSPEKDEF
     KDIVLKMRRS QQEVNFDEAL ANAYKAWMPY VIPDAAQQVL SHVANASKSD FWIVARAVSQ
     FVRDCGKLPL AGSLPDMTAS TDMFIKLQD
//